2-Hydroxy-1,5-naphthyridine
- CAS No.
- 10261-82-2
- Chemical Name:
- 2-Hydroxy-1,5-naphthyridine
- Synonyms
- 1,5-naphthyridin-2-ol;1,5-Naphthyridin-2(1H);1H-1,5-naphthyridin-2-one;1,5-Naphthyridin-2(1H)-one;1,5-Naphthyridine-2(1H)-one;2- hydroxy-1, 5-naphthidine;2-Hydroxy-1,5-naphthyridine
- CBNumber:
- CB9967359
- Molecular Formula:
- C8H6N2O
- Molecular Weight:
- 146.15
- MDL Number:
- MFCD11877925
- MOL File:
- 10261-82-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H332-H335-H319-H302-H315 |
| Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| HS Code | 2933998090 |
2-Hydroxy-1,5-naphthyridine price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 0639AA | 1,5-Naphthyridin-2(1H)-one | 10261-82-2 | 250mg | $128 | 2021-12-16 | Buy |
| AK Scientific | 0639AA | 1,5-Naphthyridin-2(1H)-one | 10261-82-2 | 1g | $250 | 2021-12-16 | Buy |
| Apolloscientific | OR901584 | 1,5-Naphthyridin-2(1H)-one 98% | 10261-82-2 | 1g | $269 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0386859 | 1,5-NAPHTHYRIDIN-2(1H)-ONE 95.00% | 10261-82-2 | 5MG | $505.91 | 2021-12-16 | Buy |
| Apolloscientific | OR901584 | 1,5-Naphthyridin-2(1H)-one 98% | 10261-82-2 | 5g | $805 | 2021-12-16 | Buy |
2-Hydroxy-1,5-naphthyridine Chemical Properties,Uses,Production
Uses
1,5-Naphthyridin-2(1H)-one is used as a reactant in the design of brain penetrant JNK inhibitors for prevention of neurodegeneration.
Synthesis
![2-Methoxy-[1,5]naphthyridine](/CAS/20180703/GIF/CB73170978.gif)
27017-69-2
10261-82-2
The general procedure for the synthesis of 1,5-naphthyridin-2(1H)-one from the compound (CAS: 27017-69-2) was as follows: intermediate 2 (15.8 g) was dissolved in 6N hydrochloric acid solution (100 mL) and the reaction was stirred at 110 °C for 2 h. The reaction was carried out at 0 °C for 2 h. The reaction was carried out at 0 °C for 2 h. The solid was dried by suction filtration. Upon completion of the reaction, the reaction mixture was cooled to 0 °C and the pH was adjusted to 6-7 with solid sodium hydroxide. the precipitated solid was separated by filtration and dried by suction with a sintered funnel for 2 h, followed by vacuum drying at 45 °C to afford the target product 1,5-naphthyridin-2(1H)-one (14.4 g, 98% yield). [ES MS] m/z 147 (MH+).
References
[1] Patent: EP2080761, 2009, A1. Location in patent: Page/Page column 16
[2] Patent: WO2010/81874, 2010, A1. Location in patent: Page/Page column 18
2-Hydroxy-1,5-naphthyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29733 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8285 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5661 | 58 |
| Yangzhou Model Electronic Materials Co., Ltd. | +8613761402923 | sales@modeltemol.com | CHINA | 571 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 19957148339; | market18@leapchem.com | China | 24727 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 |
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