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Zilucoplan

Zilucoplan Structure
Zilucoplan structure
CAS No.
1841136-73-9
Chemical Name:
Zilucoplan
Synonyms
Zilucoplan sodium;RA101495;Zilucoplan;Poly(oxy-1,2-ethanediyl), α-[2-[[(4S)-4-carboxy-1-oxo-4-(1-oxohexadecyl)butyl]amino]ethyl]-ω-hydroxy-, 15-ether with N-acetyl-L-lysyl-L-valyl-L-α-glutamyl-L-arginyl-L-phenylalanyl-L-α-aspartyl-N-methyl-L-α-aspartyl-3-methyl-L-valyl-L-tyrosyl-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-L-alanyl-L-α-glutamyl-L-tyrosyl-L-prolyl-(2S)-2-cyclohexylglycyl-N6-(3-hydroxy-1-oxopropyl)-L-lysine (6→1)-lactam;Poly(oxy-1,2-ethanediyl), α-[2-[[(4S)-4-carboxy-1-oxo-4-(1-oxohexadecyl)butyl]amino]ethyl]-ω-hydroxy-, 15-ether with N-acetyl-L-lysyl-L-valyl-L-α-glutamyl-L-arginyl-L-phenylalanyl-L-α-aspartyl-N-methyl-L-α-aspartyl-3-methyl-L-valyl-L-tyrosyl-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-L-alanyl-L-α-glutamyl-L-tyrosyl-L-prolyl-(2S)-2-cyclohexylglycyl-N6-(3-hydroxy-1-oxopropyl)-L-lysine (6→1)-lactam (ACI)
CBNumber:
CB99704201
Molecular Formula:
(C2H4O)nC126H186N24O32
Molecular Weight:
0
MDL Number:
MOL File:
1841136-73-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-21 16:59:09
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Zilucoplan Properties

form Solid
color White to off-white
FDA UNII YG391PK0CC
NCI Drug Dictionary zilucoplan

Zilucoplan price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth PZ09995 Zilucoplan 1841136-73-9 100mg $5875 2026-06-04 Buy
ChemScene CS-0615017 Zilucoplan 99.71% 1841136-73-9 1mg $596 2026-06-04 Buy
ChemScene CS-0615017 Zilucoplan 99.71% 1841136-73-9 5mg $1354 2026-06-04 Buy
ChemScene CS-0615017 Zilucoplan 99.71% 1841136-73-9 10mg $2199 2026-06-04 Buy
aablocks AA029OBW Zilucoplan >98% 1841136-73-9 1mg $647 2026-06-02 Buy
Product number Packaging Price Buy
PZ09995 100mg $5875 Buy
CS-0615017 1mg $596 Buy
CS-0615017 5mg $1354 Buy
CS-0615017 10mg $2199 Buy
AA029OBW 1mg $647 Buy

Zilucoplan Chemical Properties,Uses,Production

Uses

Zilucoplan (RA101495), a 15-amino acid macrocyclic peptide, is a potent complement component 5 (C5) inhibitor. Zilucoplan can be used in research of immune-mediated necrotising myopathy (IMNM)[1][2].

in vivo

Zilucoplan (RA101495; 10 mg/kg; S.C.; daily, for 6 d) prevents the development of immune-mediated necrotising myopathy (IMNM) in C5-deficient mice supplemented with human complement[1].
Zilucoplan (10 mg/kg; S.C.; daily, for 6 d) has protection on myopathy prevention in C57BL/6 mice[1].

Animal Model:C57BL/10SnJ C5-deficient (C5def) mice with anti-HMGCR+ IMNM IgG xenografts[1]
Dosage:10 mg/kg
Administration:Subcutaneous injection; daily, for 6 days
Result:Prevented muscle strength loss in C5def mice with less complement deposition on myofibres and consequently less necrosis/regeneration.
Animal Model:C57BL/6 mice with anti-HMGCR+ IMNM IgG xenografts[1]
Dosage:10 mg/kg
Administration:Subcutaneous injection; daily, for 6 days
Result:Prevented muscle weakness and reduced regenerated myofibres.
Decreased necrotic cells as well as regenerating cells expressing foetal myosin.

References

[1] Julien S, et, al. Prevention of Anti-HMGCR Immune-Mediated Necrotising Myopathy by C5 Complement Inhibition in a Humanised Mouse Model. Biomedicines. 2022 Aug 20;10(8):2036. DOI:10.3390/biomedicines10082036
[2] Gorman DM, et, al. Chemical synthesis and characterisation of the complement C5 inhibitory peptide zilucoplan. Amino Acids. 2021 Jan;53(1):143-147. DOI:10.1007/s00726-020-02921-5

Zilucoplan Preparation Products And Raw materials

Raw materials

Preparation Products

Zilucoplan Suppliers

Global( 24)Suppliers
Supplier Tel Email Country ProdList Advantage
Taizhou Zhongzhi Biotechnology Co., Ltd zhongzhipharma@126.c 15066129350 zhongzhipharma@126.com China 9963 58
Apextide Co Ltd 15300650552; 15300650552 info@apextide.com China 90 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919 15967184799 Eric@peptidego.com China 7872 58
BOC Sciences +1-631-485-4226 inquiry@bocsci.com United States 19935 58
Shanghai Peiling Biological Technology Co., LTD 13127581762 13127581762 peilingchem@sina.com China 465 58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD 0571-87213919 17306812703 3007955328@qq.com China 7446 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 086-15871494362 13720134139 orders@jknbiochem.com China 7283 58
Suzhou Haiben Pharmaceutical Co., Ltd 19353112242 1816280386@qq.com China 8041 58
Changsha Fuzhen Biotechnology Co.，LTD 15111215862 18229892877 3062105966@qq.com China 5550 58
Supplier Advantage
Taizhou Zhongzhi Biotechnology Co., Ltd 58
Apextide Co Ltd 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Hangzhou Peptidego Biotech Co.,Ltd. 58
BOC Sciences 58
Shanghai Peiling Biological Technology Co., LTD 58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 58
Suzhou Haiben Pharmaceutical Co., Ltd 58
Changsha Fuzhen Biotechnology Co.，LTD 58

View Lastest Price from Zilucoplan manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Zilucoplan pictures 2026-07-22 Zilucoplan
1841136-73-9
 1kg 98 1000kgs Shaanxi Dideu New Materials Co. Ltd
  • Zilucoplan pictures
  • Zilucoplan
    1841136-73-9
  • $0.00
  • 98
  • Shaanxi Dideu New Materials Co. Ltd

1841136-73-9(Zilucoplan)Related Search:

C2/Complement C2 Protein, Human (HEK293, His) CFHR1 Protein, HUMAN (HEK293, HIS) COMPLEMENT FACTOR D/ADIPSIN PROTEIN, MOUSE (HEK293, FC) MBL2/COLEC1 Protein, HUMAN (HEK293, HIS) Eculizumab
EG00229

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Zilucoplan RA101495 Poly(oxy-1,2-ethanediyl), α-[2-[[(4S)-4-carboxy-1-oxo-4-(1-oxohexadecyl)butyl]amino]ethyl]-ω-hydroxy-, 15-ether with N-acetyl-L-lysyl-L-valyl-L-α-glutamyl-L-arginyl-L-phenylalanyl-L-α-aspartyl-N-methyl-L-α-aspartyl-3-methyl-L-valyl-L-tyrosyl-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-L-alanyl-L-α-glutamyl-L-tyrosyl-L-prolyl-(2S)-2-cyclohexylglycyl-N6-(3-hydroxy-1-oxopropyl)-L-lysine (6→1)-lactam Zilucoplan sodium Poly(oxy-1,2-ethanediyl), α-[2-[[(4S)-4-carboxy-1-oxo-4-(1-oxohexadecyl)butyl]amino]ethyl]-ω-hydroxy-, 15-ether with N-acetyl-L-lysyl-L-valyl-L-α-glutamyl-L-arginyl-L-phenylalanyl-L-α-aspartyl-N-methyl-L-α-aspartyl-3-methyl-L-valyl-L-tyrosyl-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-L-alanyl-L-α-glutamyl-L-tyrosyl-L-prolyl-(2S)-2-cyclohexylglycyl-N6-(3-hydroxy-1-oxopropyl)-L-lysine (6→1)-lactam (ACI) 1841136-73-9