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ChemicalBook >> CAS DataBase List >>5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)-

5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)-

5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- Structure
5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- structure
CAS No.
1802518-92-8
Chemical Name:
5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)-
Synonyms
Minzasolmin;5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)-
CBNumber:
CB99809366
Molecular Formula:
C23H31N5OS
Molecular Weight:
425.59
MDL Number:
MOL File:
1802518-92-8.mol
Last updated:2026-01-15 14:49:44
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5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- Properties

Density 1.209±0.06 g/cm3(Predicted)
form Solid
pka 13.93±0.46(Predicted)
color Off-white to light yellow
FDA UNII 3N0435TG2D

5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- Chemical Properties,Uses,Production

Uses

Minzasolmin (NPT200-11; UCB0599) is an orally active, blood-brain-permeable α-synuclein (α-Syn) inhibitor that selectively binds to α-Syn misfolded intermediates (such as oligomers) and inhibits aggregation and fibril formation by regulating their conformational stability. Minzasolmin can reduce the generation of pathological oligomers and block neurotoxic signaling, thereby reducing the abnormal accumulation of α-Syn in the brain. Minzasolmin significantly improved motor deficits, reduced neuroinflammatory markers, and α-Syn-related pathological deposition in transgenic mouse models[1][2].

in vivo

Minzasolmin (1 mg/kg, 5 mg/kg; intraperitoneal injection; once a day, 5 days a week; 3 months) significantly improves motor coordination ability (such as prolonged rotarod test time), reduces α-synuclein (α-Syn) pathological deposition and neuroinflammatory markers (such as reduced IL-6 levels) in the cerebral cortex and hippocampus, and restores striatal dopamine transporter (DAT) levels in the Thy1-αSyn transgenic mouse model[1].

Animal Model:Female Thy1-αSyn transgenic mice[2]
Dosage:1 mg/kg or 5 mg/kg, dissolved in DMSO/saline
Administration:Intraperitoneal (IP) injection, daily (Monday to Friday), 3-month treatment period
Result: Significantly improved motor coordination (rotarod latency increased by 20% in 5 mg/kg group) and reduced gait abnormalities compared to vehicle controls.
Western blot analysis showed a dose-dependent decrease in insoluble α-synuclein (α-Syn) aggregates in the cortex and hippocampus (50% reduction at 5 mg/kg), accompanied by downregulation of neuroinflammatory markers (IL-6, TNF-α) and normalization of striatal dopamine transporter (DAT) levels.
Immunohistochemistry revealed fewer phosphorylated α-Syn (p-Ser129) positive inclusions in substantia nigra neurons, indicating attenuation of α-Syn pathology and neuroinflammation.

IC 50

α-synuclein Aggregation

References

[1] Steiner MA. Matters arising: In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson's disease. NPJ Parkinsons Dis. 2024 Mar 14;10(1):59. DOI:10.1038/s41531-024-00657-7
[2] Baggett, et al. Novel Approaches Targeting in α-Synuclein for Parkinson's Disease: Current Progress and Future Directions for the Disease-Modifying Therapies. Brain Disorders (2024): 100163.

5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- Suppliers

Global( 13)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32470 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185; sales-cpd@caerulumpharma.com China 3505 58
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9810 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24962 58
Shanghai Easy CDMO Co.,Ltd 021-61734564 13854185395; info@easycdmo.com China 10024 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 6710 58
Aikon International Limited 025-58851090 13408877820 2850281427@qq.com China 10000 58
Shanghai Amole Biotechnology Co., Ltd. 18916360931 18916360931 2596183085@qq.com China 17236 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Chunchuang (Wuhan) Technology Co., Ltd 58
TargetMol Chemicals Inc. 58
Shanghai Easy CDMO Co.,Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
RD International Technology Co., Limited 58
Sangon Biotech (Shanghai) Co.,Ltd. 58
Aikon International Limited 58
Shanghai Amole Biotechnology Co., Ltd. 58

View Lastest Price from 5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Minzasolmin pictures 2026-01-15 Minzasolmin
1802518-92-8
 US $245.00-988.00 / mg 99.95% 10g TargetMol Chemicals Inc.
  • Minzasolmin pictures
  • Minzasolmin
    1802518-92-8
  • US $245.00-988.00 / mg
  • 99.95%
  • TargetMol Chemicals Inc.
5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- Minzasolmin 1802518-92-8