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ChemicalBook >> CAS DataBase List >>5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)-

5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)-

5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- Structure
5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- structure
CAS No.
1802518-92-8
Chemical Name:
5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)-
Synonyms
Minzasolmin;5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)-;N-[(1R)-1-(1H-Indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)-5-thiazolecarboxamide (ACI)
CBNumber:
CB99809366
Molecular Formula:
C23H31N5OS
Molecular Weight:
425.59
MDL Number:
MOL File:
1802518-92-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- Properties

Density 1.209±0.06 g/cm3(Predicted)
form Solid
pka 13.93±0.46(Predicted)
color Off-white to light yellow
FDA UNII 3N0435TG2D

5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0376408 Minzasolmin 98.60% 1802518-92-8 1mg $323 2026-06-04 Buy
ChemScene CS-0376408 Minzasolmin 98.60% 1802518-92-8 5mg $810 2026-06-04 Buy
ChemScene CS-0376408 Minzasolmin 98.60% 1802518-92-8 10mg $1295 2026-06-04 Buy
ChemScene CS-0376408 Minzasolmin 98.60% 1802518-92-8 25mg $2329 2026-06-04 Buy
ChemScene CS-0376408 Minzasolmin 98.60% 1802518-92-8 50mg $3467 2026-06-04 Buy
Product number Packaging Price Buy
CS-0376408 1mg $323 Buy
CS-0376408 5mg $810 Buy
CS-0376408 10mg $1295 Buy
CS-0376408 25mg $2329 Buy
CS-0376408 50mg $3467 Buy

5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- Chemical Properties, Uses, Production

Uses

Minzasolmin (NPT200-11; UCB0599) is an orally active, blood-brain-permeable α-synuclein (α-Syn) inhibitor that selectively binds to α-Syn misfolded intermediates (such as oligomers) and inhibits aggregation and fibril formation by regulating their conformational stability. Minzasolmin can reduce the generation of pathological oligomers and block neurotoxic signaling, thereby reducing the abnormal accumulation of α-Syn in the brain. Minzasolmin significantly improved motor deficits, reduced neuroinflammatory markers, and α-Syn-related pathological deposition in transgenic mouse models[1][2].

in vivo

Minzasolmin (1 mg/kg, 5 mg/kg; intraperitoneal injection; once a day, 5 days a week; 3 months) significantly improves motor coordination ability (such as prolonged rotarod test time), reduces α-synuclein (α-Syn) pathological deposition and neuroinflammatory markers (such as reduced IL-6 levels) in the cerebral cortex and hippocampus, and restores striatal dopamine transporter (DAT) levels in the Thy1-αSyn transgenic mouse model[1].

Animal Model:Female Thy1-αSyn transgenic mice[2]
Dosage:1 mg/kg or 5 mg/kg, dissolved in DMSO/saline
Administration:Intraperitoneal (IP) injection, daily (Monday to Friday), 3-month treatment period
Result: Significantly improved motor coordination (rotarod latency increased by 20% in 5 mg/kg group) and reduced gait abnormalities compared to vehicle controls.
Western blot analysis showed a dose-dependent decrease in insoluble α-synuclein (α-Syn) aggregates in the cortex and hippocampus (50% reduction at 5 mg/kg), accompanied by downregulation of neuroinflammatory markers (IL-6, TNF-α) and normalization of striatal dopamine transporter (DAT) levels.
Immunohistochemistry revealed fewer phosphorylated α-Syn (p-Ser129) positive inclusions in substantia nigra neurons, indicating attenuation of α-Syn pathology and neuroinflammation.

IC 50

α-synuclein Aggregation

References

[1] Steiner MA. Matters arising: In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson's disease. NPJ Parkinsons Dis. 2024 Mar 14;10(1):59. DOI:10.1038/s41531-024-00657-7
[2] Baggett, et al. Novel Approaches Targeting in α-Synuclein for Parkinson's Disease: Current Progress and Future Directions for the Disease-Modifying Therapies. Brain Disorders (2024): 100163.

5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- Suppliers

Global Suppliers ( 14)
Supplier Tel Email Country ProdList Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9867 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Shandong Dayou Pharmaceutical Research and Development Co., Ltd. hanfangpharma@126.com 15165037910 hanfangpharma@126.com China 25800 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9831 58
Shanghai Amole Biotechnology Co., Ltd. 13370042665 18916960931 2596183085@qq.com China 17234 58
Qingdao Haizhi Weiyuan Biotechnology Co., Ltd. 18317699790 18317699790 l202008112023@163.com China 7733 58
Supplier Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
TargetMol Chemicals Inc. 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Shandong Dayou Pharmaceutical Research and Development Co., Ltd. 58
RD International Technology Co., Limited 58
Shanghai Amole Biotechnology Co., Ltd. 58
Qingdao Haizhi Weiyuan Biotechnology Co., Ltd. 58

View Latest Price from 5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Minzasolmin pictures 2026-07-15 Minzasolmin
1802518-92-8
 $245.00-988.00 99.95% 10g TargetMol Chemicals Inc.
  • Minzasolmin pictures
  • Minzasolmin
    1802518-92-8
  • $245.00-988.00
  • 99.95%
  • TargetMol Chemicals Inc.

1802518-92-8 (5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)-) Related Search:

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5-Thiazolecarboxamide, N-[(1R)-1-(1H-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)- Minzasolmin N-[(1R)-1-(1H-Indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)-5-thiazolecarboxamide (ACI) 1802518-92-8