2-(4-ピリジル)-6,7-ジヒドロ-1H-ピロロ[3,2-c]ピリジン-4(5H)-オン
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- CAS番号.
- 845714-00-3
- 化学名:
- 2-(4-ピリジル)-6,7-ジヒドロ-1H-ピロロ[3,2-c]ピリジン-4(5H)-オン
- 别名:
- 2-(4-ピリジル)-6,7-ジヒドロ-1H-ピロロ[3,2-c]ピリジン-4(5H)-オン;2-(ピリジン-4-イル)-1H,4H,5H,6H,7H-ピロロ[3,2-c]ピリジン-4-オン
- 英語名:
- PHA 767491 HYDROCHLORIDE
- 英語别名:
- CS-229;CAY10572;PHA-767491;PHA-767491HCL;Cdc7/Cdk9 Inhibitor;CAY10572(PHA-767491);PHA 767491;PHA-767491;PHA-767491 (CAY10572);PHA 767491 HYDROCHLORIDE;PHA-767491, 10 mM in DMSO
- CBNumber:
- CB02458643
- 化学式:
- C12H11N3O
- 分子量:
- 213.24
- MOL File:
- 845714-00-3.mol
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2-(4-ピリジル)-6,7-ジヒドロ-1H-ピロロ[3,2-c]ピリジン-4(5H)-オン 物理性質
- 比重(密度) :
- 1.287
- 貯蔵温度 :
- Desiccate at RT
- 溶解性:
- insoluble in H2O; insoluble in EtOH; ≥10.65 mg/mL in DMSO
- 外見 :
- solid
- 色:
- Off-white to light yellow
- 安定性::
- Hygroscopic
- CAS データベース:
- 845714-00-3
安全性情報
2-(4-ピリジル)-6,7-ジヒドロ-1H-ピロロ[3,2-c]ピリジン-4(5H)-オン 価格
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2-(4-ピリジル)-6,7-ジヒドロ-1H-ピロロ[3,2-c]ピリジン-4(5H)-オン 化学特性,用途語,生産方法
使用
Cdc7 kinase is a key regulator of the S-phase of the cell cycle. It is known to promote the activity of DNA replication origins in eukaryotic organisms. Inhibition of Cdc7 kinase causes blockade of DNA synthesis in human cell lines. Tumor cells are then funneled into the apoptotic pathway in a p53-independent manner. Pharmacological inhibition of Cdc7 kinase can be an effective strategy for the development of oncologic therapeutics useful for treatment of cancers. PHA 767491 HYDROCHLORIDE is a potent inhibitor of Cdc7 kinase with an IC50 value of 10 nM in the presence of 1.5 μM ATP. At 10 μM, PHA 767491 HYDROCHLORIDE induces apoptotic cell death in multiple cancer cell types. PHA 767491 HYDROCHLORIDE also inhibits Cdk9, a kinase involved in the phosphorylation of RNA polymerase II and in transcriptional regulation of gene expression, with an IC50 value of 34 nM.[Cayman Chemical]
生物活性
Potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC 50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. Inhibits cell proliferation in a variety of human cell lines (IC 50 ~ 0.86 - 5.87 μ M) and induces apoptosis in a p53-independent manner in vivo . Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2) (IC 50 = 171 nM).
2-(4-ピリジル)-6,7-ジヒドロ-1H-ピロロ[3,2-c]ピリジン-4(5H)-オン 上流と下流の製品情報
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2-(4-ピリジル)-6,7-ジヒドロ-1H-ピロロ[3,2-c]ピリジン-4(5H)-オン 生産企業
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2-(4-ピリジル)-6,7-ジヒドロ-1H-ピロロ[3,2-c]ピリジン-4(5H)-オン スペクトルデータ(1HNMR)
845714-00-3(2-(4-ピリジル)-6,7-ジヒドロ-1H-ピロロ[3,2-c]ピリジン-4(5H)-オン)キーワード:
- 845714-00-3
- PHA-767491
- CAY10572
- 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one
- PHA 767491 HYDROCHLORIDE
- 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-onehydrochloride
- 2-(pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one
- 2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
- PHA-767491HCL
- PHA-767491;CAY10572;PHA767491;PHA 767491
- PHA-767491 (CAY10572)
- PHA 767491;PHA-767491
- CS-229
- CAY10572(PHA-767491)
- 4H-Pyrrolo[3,2-c]pyridin-4-one, 1,5,6,7-tetrahydro-2-(4-pyridinyl)-
- PHA 767491 HYDROCHLORIDE USP/EP/BP
- PHA-767491 PHA767491 Dihydrochloride Salt
- PHA-767491, 10 mM in DMSO
- Cdc7/Cdk9 Inhibitor
- 2-(4-ピリジル)-6,7-ジヒドロ-1H-ピロロ[3,2-c]ピリジン-4(5H)-オン
- 2-(ピリジン-4-イル)-1H,4H,5H,6H,7H-ピロロ[3,2-c]ピリジン-4-オン