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Lys05

化学構造式
1391426-24-6
CAS番号.
1391426-24-6
化学名:
别名:
英語名:
Lys05
英語别名:
LSY-05;Lys01 3HCl;lys05(3hcl);Lys05 >=98% (HPLC);Lys05, 10 mM in DMSO;Lys05 (hydrochloride);Lys05 trihydrochloride;Lys01 (trihydrochloride);Lys05 (Lys01 trihydrochloride);Inhibitor,Lys-05,Autophagy,inhibit,Lys 05,Lys05
CBNumber:
CB03166387
化学式:
C23H24Cl3N5
分子量:
476.83
MOL File:
1391426-24-6.mol
MSDS File:
SDS

Lys05 物理性質

貯蔵温度 :
Store at -20°C
溶解性:
DMSO:12.0(Max Conc. mg/mL);21.83(Max Conc. mM)
Water:4.7(Max Conc. mg/mL);8.55(Max Conc. mM)
外見 :
A crystalline solid
色:
Light brown to gray
InChIKey:
KXCXCUSYQCJULU-UHFFFAOYSA-N
SMILES:
N(C1=CC=NC2C=C(Cl)C=CC1=2)CCN(C)CCNC1=CC=NC2C=C(Cl)C=CC1=2.Cl

安全性情報

WGK Germany  WGK 3
ストレージクラス 11 - Combustible Solids

Lys05 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

Lys05 化学特性,用途語,生産方法

Biochem/physiol Actions

Lys05 (Lys01 trihydrochloride) is a dimeric chloroquine (CQ) that deacidifies the lysosome and causes impairment of lysosomal enzymes, exhibiting more than 10-fold higher autophagy inhibitory potency than hydroxychloroquine (HCQ) and CQ (LC3II/LC3I ratio = 15.4 post 4 hr 10 μM treatment in LN229 glioblastoma cells vs. <6.4 with 100 μM CQ or HCQ). Lys05 also shows higher anticancer activity both in vitro (IC50 3.6-6.0 μM vs. 15.6-23.8 μM with HCQ in 1205Lu, c8161, LN229, HT-29 cultures) and in mice in vivo (EC50 in reducing tumor growth rate ～10 mg/kg/day i.p.; HT29 xenografts) with toxicity observed only at high doses (≥80 mg/kg) as a result of significant lysozyme reduction.

Lys05 上流と下流の製品情報

原材料

準備製品

Lys05 生産企業

Global( 88)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
Changzhou Borl Biotechnology Co.,LTD 13656121842
 luyan0021@163.com China 265 58
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097
 sales.bj@hwrkchemical.com China 9407 55
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057
 3003855609@qq.com China 7717 56
ShangHai Angti Biotechnology Co., Ltd. 13764913901
 info@angtibio.com China 4975 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105
 2881489226@qq.com China 89667 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
 klq@cw-bio.com China 9780 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994
 2853530910@QQ.com China 8000 62
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686
 sales@rechemscience.com China 2969 58
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235
 Sales@ATKchemical.com China 9729 58
Beijing Solarbio Science & Tecnology Co., Ltd. 17801761073 18101056239
 3193328036@qq.com China 28150 68

  スペクトルデータ(1HNMR)

Lys05(1391426-24-6)1HNMR

1391426-24-6()キーワード:

N-(2-ピリジル)-2-ピリジンカルボチオアミド BGT-226 レベルシン ドルソモルフィン二塩酸塩 4-({9-シクロペンチル-7,7-ジフルオロ-5-メチル-6-オキソ-5H,6H,7H,8H,9H-ピリミド[4,5-b][1,4]ジアゼピン-2-イル}アミノ)-3-メトキシ-N-(1-メチルピペリジン-4-イル)ベンズアミド コルホルシン
  • 1391426-24-6
  • Lys01 (trihydrochloride)
  • lys05(3hcl)
  • Lys05 trihydrochloride
  • Lys01 3HCl
  • Lys05 (Lys01 trihydrochloride)
  • Lys05 >=98% (HPLC)
  • Lys05 (hydrochloride)
  • N1-(7-Chloroquinolin-4-yl)-N2-(2-((7-chloroquinolin-4-yl)amino)ethyl)-N2-methylethane-1,2-diamine trihydrochloride
  • Inhibitor,Lys-05,Autophagy,inhibit,Lys 05,Lys05
  • LSY-05
  • Lys05, 10 mM in DMSO
  • N-(7-chloroquinolin-4-yl)-N'-[2-[(7-chloroquinolin-4-yl)amino]ethyl]-N'-methylethane-1,2-diamine
  • N'-(7-Chloroquinolin-4-yl)-N-{2-[(7-chloroquinolin-4-yl)amino]ethyl}-N-methylethane-1,2-diamine trihydrochloride
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