ベナクチジン
ベナクチジン 物理性質
- 融点 :
- 51°
- 沸点 :
- 465.31°C (rough estimate)
- 比重(密度) :
- 1.1392 (rough estimate)
- 屈折率 :
- 1.5614 (estimate)
- 貯蔵温度 :
- 2-8°C
- 酸解離定数(Pka):
- 11.31±0.29(Predicted)
- NISTの化学物質情報:
- Benactyzine(302-40-9)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 主な危険性 |
T |
|
|
| Rフレーズ |
23/24/25 |
|
|
| Sフレーズ |
36/37/39-45 |
|
|
| 有毒物質データの |
302-40-9(Hazardous Substances Data) |
|
|
| 毒性 |
human,TDLo,intramuscular,100ug/kg (0.1mg/kg),SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE,"Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85Vol. 1, Pg. L1, 1982. |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
|
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
| H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
|
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
呼吸器への刺激のおそれ |
特定標的臓器毒性、単回暴露； 気道刺激性 |
3 |
警告 |
|
|
|
| 注意書き |
| P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
| P305+P351+P338 |
眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
|
ベナクチジン 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
ベナクチジン 化学特性,用途語,生産方法
効能
抗不安薬, 気管支拡張薬
Originator
Suavitil,Merck Sharp and
Dohme,US,1957
Manufacturing Process
114 parts of ethyl benzilate, 175 parts of β-diethylaminoethanol and 0.2 part
of metallic sodium were placed in a flask attached to a total-reflux variable
take-off fractionating column. The pressure was reduced to 100 mm and heat
was applied by an oil bath the temperature of which was slowly raised to
90°C. During three hours of heating 17 parts of ethanol distilled (35.5°C).
When the distillation of the ethanol became slow, the bath temperature was
raised to 120°C. When the vapor temperature indicated distillation of the
amino alcohol the take off valve was closed and the mixture was refluxed for
one hour. At the end of this period the vapor temperature had dropped and
two more parts of ethanol were distilled, The remaining aminoalcohol was
slowly distilled for three hours. The pressure was then reduced to 20 mm and
the remainder of the aminoalcohol distilled at 66°C. During the reaction the
color of the solution changed from yellow to deep red. The residue was
dissolved in 500 parts of ether, washed once with dilute brine, and three times
with water, dried over sodium sulfate and finally dried over calcium sulfate.
500 parts of a saturated solution of HCl in absolute ether was added and the
resulting precipitate filtered. Dry HCl gas was passed into the filtrate to a
slight excess and the precipitate again filtered. The combined precipitates
were washed with cold acetone. The 106 parts of product was purified by
recrystallization from acetone as fine white crystals which melt at 177°-
178°C.
Therapeutic Function
Tranquilizer; Anticholinergic
ベナクチジン 上流と下流の製品情報
原材料
準備製品
ベナクチジン 生産企業
Global( 31)Suppliers
302-40-9(ベナクチジン)キーワード:
- 302-40-9
- 2-diethylaminoethyl 2-hydroxy-2,2-diphenyl-acetate
- benactyzine
- Benactyzine (base and/or unspecified salts)
- 2-Diethylaminoethyl benzilate
- Benzilic acid, 2-(diethylamino)ethyl ester
- Diethylaminoethyl benzilate
- Benactyzin
- Diphenylglycolic acid 2-(diethylamino)ethyl ester
- α-Hydroxy-α-phenylbenzeneacetic acid 2-(diethylamino)ethyl
- α-Hydroxy-α-phenylbenzeneacetic acid 2-(diethylamino)ethyl ester
- 2-diethylaminoethyl 2-hydroxy-2,2-di(phenyl)ethanoate
- 2-hydroxy-2,2-di(phenyl)acetic acid 2-diethylaminoethyl ester
- IVQOFBKHQCTVQV-UHFFFAOYSA-N
- Benzeneacetic acid, α-hydroxy-α-phenyl-, 2-(diethylamino)ethyl ester
- Benactyzine USP/EP/BP
- Flamprop-methyl Impurity 8
- ジフェニルグリコール酸ジエチルアミノエチル
- ジフェニルグリコール酸2-(ジエチルアミノ)エチル
- ベンジル酸2-(ジエチルアミノ)エチル
- ベナクチジン
- ダイアジル
- 2-ヒドロキシ-2,2-ジフェニル酢酸2-(ジエチルアミノ)エチル
- ジアジル
- ヒドロキシジフェニル酢酸2-(ジエチルアミノ)エチル
- α-ヒドロキシ-α-フェニル-ベンゼン酢酸2-(ジエチルアミノ)エチル
- α-ヒドロキシ-α-フェニルベンゼン酢酸2-(ジエチルアミノ)エチル
- 2-(ジエチルアミノ)エチル 2-ヒドロキシ-2,2-ジフェニルアセタート
- ジフェニルメタン系抗不安薬
- 抗コリン作動薬