バルニジピン塩酸塩
|
|
|
- CAS番号.
- 104757-53-1
- 化学名:
- バルニジピン塩酸塩
- 别名:
- ヒポカ;(4S)-2,6-ジメチル-1,4-ジヒドロ-4-(3-ニトロフェニル)ピリジン-3,5-ジカルボン酸5-メチル3-[(3S)-1-ベンジルピロリジン-3-イル]·塩酸塩;塩酸バルニジピン;(4S)-2,6-ジメチル-4-(3-ニトロフェニル)-1,4-ジヒドロピリジン-3,5-ジカルボン酸3-メチル5-[(3S)-1-ベンジルピロリジン-3-イル]·塩酸塩;(4S)-1,4-ジヒドロ-2,6-ジメチル-4-(3-ニトロフェニル)ピリジン-3,5-ジカルボン酸5-メチル3-[(3S)-1-ベンジルピロリジン-3-イル]·塩酸塩;バルニジピン塩酸塩;塩酸メピロジピン;バルニジピン塩酸塩 (JAN);(4S)-2,6-ジメチル-1,4-ジヒドロ-4-(3-ニトロフェニル)ピリジン-3,5-ジカルボン酸5-メチル3-[(3S)-1-ベンジルピロリジン-3-イル]・塩酸塩;(4S)-1,4-ジヒドロ-2,6-ジメチル-4-(3-ニトロフェニル)ピリジン-3,5-ジカルボン酸5-メチル3-[(3S)-1-ベンジルピロリジン-3-イル]・塩酸塩;YM-730;(4S)-2,6-ジメチル-4-(3-ニトロフェニル)-1,4-ジヒドロピリジン-3,5-ジカルボン酸3-メチル5-[(3S)-1-ベンジルピロリジン-3-イル]・塩酸塩
- 英語名:
- Barnidipine hydrochloride
- 英語别名:
- ym730;Hypoca;ly198561;ym09730-5;Mepirodipine;BARNIDIPINE HCL;YM-09730-5：Hypoca;BARNIDIPINE HYDROCHLORIDE;mepirodipinehydrochloride;Barnidipine Hydrochloride l
- CBNumber:
- CB1397277
- 化学式:
- C27H30ClN3O6
- 分子量:
- 528
- MOL File:
- 104757-53-1.mol
|
バルニジピン塩酸塩 物理性質
- 融点 :
- 223-226°C
- 比旋光度 :
- D20 +116.4° (c = 1 in methanol)
- 貯蔵温度 :
- Sealed in dry,Room Temperature
- 溶解性:
- insoluble in H2O; insoluble in EtOH; ≥16.3 mg/mL in DMSO with gentle warming
- 外見 :
- A crystalline solid
- 色:
- Light yellow to yellow
- CAS データベース:
- 104757-53-1(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 毒性 |
LD50 orally in male, female rats: 105, 113 mg/kg (Satoh) |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H317 |
アレルギー性皮膚反応を起こすおそれ |
感作性、皮膚 |
1 |
警告 |
|
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
|
P264, P280, P305+P351+P338,P337+P313P |
|
| 注意書き |
| P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
| P305+P351+P338 |
眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
|
バルニジピン塩酸塩 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
バルニジピン塩酸塩 化学特性,用途語,生産方法
効能
血圧降下薬, カルシウムチャネル遮断薬
商品名
ヒポカ (LTLファーマ)
説明
Barnidipine hydrochloride, chemically known as (3S)-1-benzyl-3-pyrrolidinylmethyl-(4S)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride, is a new long-acting dihydropyridine calcium antagonist developed and marketed by Yamanouchi Pharmaceutical (now Astellas Pharma). This medication effectively lowers blood pressure without impacting heart rate by specifically targeting calcium channels responsible for transmembrane potential. By inhibiting calcium influx into cells, it selectively relaxes smooth muscle in peripheral and coronary blood vessels.
化学的特性
Pale Yellow Solid. Melting point 226-228°C. [α]D20+116.4° (C=1, methanol). Insoluble in water. Acute toxicity LD50 male and female rats (mg/kg): 105, 113 Oral.
使用
Barnidipine hydrochloride is a vasodilating dihydropyridine calcium antagonist useful in the treatment of primary hypertension and renal hypertension. In experimental animals, its hypotensive effect was more potent and longer acting than nicardipine, nifedipine and nitrendipine.
定義
ChEBI: Barnidipine hydrochloride is a dihydropyridine. 1,4-Dihydropyridine calcium antagonist with antihypertensive and diuretic effects. It is a potential candidate in the treatment of patients with renal parenchymal hypertension.
生物活性
Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery. It demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day. Formulations containing barnidipine have been used as a treatment for hypertension.
参考文献
[1] WEGENERJ W. Barnidipine block of L-type Ca(2+) channel currents in rat ventricular cardiomyocytes.[J]. British Journal of Pharmacology, 2000. DOI:
10.1038/sj.bjp.0703514.
[2] ALP YILDIRIMF ILKAY. Barnidipine ameliorates the vascular and renal injury in L-NAME-induced hypertensive rats.[J]. European journal of pharmacology, 2015. DOI:
10.1016/j.ejphar.2015.07.033.
[3] CHENGZHI-GANG. Synthesis and characterization of impurities of barnidipine hydrochloride, an antihypertensive drug substance.[J]. Molecules, 2014. DOI:
10.3390/molecules19011344.
バルニジピン塩酸塩 上流と下流の製品情報
原材料
準備製品
バルニジピン塩酸塩 生産企業
Global( 133)Suppliers
バルニジピン塩酸塩 スペクトルデータ(1HNMR)
104757-53-1(バルニジピン塩酸塩)キーワード:
- 104757-53-1
- hydrochloride,(s-(r*,r*))-hyl1-(phenylmethyl)-3-pyrrolidinyleste
- ly198561
- BARNIDIPINE HCL
- BARNIDIPINE HYDROCHLORIDE
- (+)-(3's,4s)-1-benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3S)-1-(phenylmethyl)-3-pyrrolidinyl ester, (4S)-
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-pyrrolidinyl ester, [S-(R*,R*)]-
- Hypoca
- Mepirodipine
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3S)-1-(phenylmethyl)-3-pyrrolidinyl ester, monohydrochloride, (4S)-
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-pyrrolidinyl ester, monohydrochloride, [S-(R*,R*)]-
- YM-09730-5：Hypoca
- (+)-(3'S,4S)-1-Benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate hydrochloride
- [S-( R^<*>^，R^<*>^)]-1，4-Dihydro-2，6-dimethyl-4-(3-nitrophenyl)-3，5-pyridinedicarboxylic acid methy11-(phenylmethyl)-3-pyrrolidinyl ester
- 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl5-[(3S)-1-(phenylmethyl)-3-pyrrolidinyl] ester, hydrochloride (1:1), (4S)-
- mepirodipinehydrochloride
- ym09730-5
- 3-((S)-1-Benzylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3
- ym730
- 3-((S)-1-Benzylpyrrolidin-3-yl) 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
- (4S)-1,4-Dihydro-2,6-diMethyl-4-(3-nitrophenyl)-3,5-Pyridinedicarboxylic Acid 3-Methyl 5-[(3S)-1-(phenylMethyl)-3-pyrrolidinyl] Ester Hydrochloride
- [S-(R*,R*)]-1,4-Dihydro-2,6-diMethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 1-(PhenylMethyl)-3-pyrrolidinyl Ester Monohydrochloride
- Barnidipine Hydrochloride l
- 3-((S)-1-Benzylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-d
- 2,6-dimethyl-4-(3-nitrophenyl)-1-(phenylmethyl)-4H-pyridine-3,5-dicarboxylic acid O3-methyl ester O5-(3-pyrrolidinyl) ester hydrochloride
- Barnidipine D5 HydrochlorideQ: What is
Barnidipine D5 Hydrochloride Q: What is the CAS Number of
Barnidipine D5 Hydrochloride Q: What is the storage condition of
Barnidipine D5 Hydrochloride Q: What are the applications of
Barnidipine D5 Hydrochloride
- 3-((S)-1-Benzylpyrrolidin-3-yl) 5-methyl (S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
- Barnidipine hydrochloride, 10 mM in DMSO
- ヒポカ
- (4S)-2,6-ジメチル-1,4-ジヒドロ-4-(3-ニトロフェニル)ピリジン-3,5-ジカルボン酸5-メチル3-[(3S)-1-ベンジルピロリジン-3-イル]·塩酸塩
- 塩酸バルニジピン
- (4S)-2,6-ジメチル-4-(3-ニトロフェニル)-1,4-ジヒドロピリジン-3,5-ジカルボン酸3-メチル5-[(3S)-1-ベンジルピロリジン-3-イル]·塩酸塩
- (4S)-1,4-ジヒドロ-2,6-ジメチル-4-(3-ニトロフェニル)ピリジン-3,5-ジカルボン酸5-メチル3-[(3S)-1-ベンジルピロリジン-3-イル]·塩酸塩
- バルニジピン塩酸塩
- 塩酸メピロジピン
- バルニジピン塩酸塩 (JAN)
- (4S)-2,6-ジメチル-1,4-ジヒドロ-4-(3-ニトロフェニル)ピリジン-3,5-ジカルボン酸5-メチル3-[(3S)-1-ベンジルピロリジン-3-イル]・塩酸塩
- (4S)-1,4-ジヒドロ-2,6-ジメチル-4-(3-ニトロフェニル)ピリジン-3,5-ジカルボン酸5-メチル3-[(3S)-1-ベンジルピロリジン-3-イル]・塩酸塩
- YM-730
- (4S)-2,6-ジメチル-4-(3-ニトロフェニル)-1,4-ジヒドロピリジン-3,5-ジカルボン酸3-メチル5-[(3S)-1-ベンジルピロリジン-3-イル]・塩酸塩
- カルシウム拮抗薬
- 降圧薬