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HS-10296

化学構造式
1899921-05-1
CAS番号.
1899921-05-1
化学名:
别名:
英語名:
HS-10296
英語别名:
HS-10296;Almonertinib;HS 10296;HS10296;2H6]-Almonertinib;Almonertinib (HS-10296);Almonertinib, 10 mM in DMSO;HS-10296;HS 10296;HS10296;1899921-05-1;N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(meth)amino)-4-methoxyphenyl)acrylamide;N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;2-Propenamide, N-[5-[[4-(1-cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-
CBNumber:
CB14808621
化学式:
C30H35N7O2
分子量:
525.66
MOL File:
1899921-05-1.mol

HS-10296 物理性質

比重(密度) :
1.24±0.1 g/cm3(Predicted)
溶解性:
DMSO:91.67(Max Conc. mg/mL);174.38(Max Conc. mM)
Ethanol:6.0(Max Conc. mg/mL);11.41(Max Conc. mM)
酸解離定数(Pka):
12.68±0.70(Predicted)
外見 :
Solid
色:
Off-white to light yellow

安全性情報

HS-10296 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

HS-10296 化学特性,用途語,生産方法

使用

Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer.

HS-10296 上流と下流の製品情報

原材料

準備製品

HS-10296 生産企業

Global( 74)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32268 58
Hubei Ipure Biology Co., Ltd 		+8613367258412
 ada@ipurechemical.com China 10244 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38663 58
Chemtour Biotech Co., Ltd 		+8617327281506
 market@chemtour.com China 1521 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8615965530500
 nickzhang@hangyubiotech.com China 10983 58

  スペクトルデータ(1HNMR)

HS-10296(1899921-05-1)1HNMR
  • 1899921-05-1
  • HS-10296
  • N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(meth)amino)-4-methoxyphenyl)acrylamide
  • HS-10296;HS 10296;HS10296;1899921-05-1
  • HS 10296;HS10296
  • Almonertinib (HS-10296)
  • Almonertinib
  • 2-Propenamide, N-[5-[[4-(1-cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-
  • N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
  • 2H6]-Almonertinib
  • inhibit,non-small,L861Q,del19,HER1,HS 10296,EGFR,mutations,L858R,lung,Inhibitor,HS10296,Almonertinib,cancer,Epidermal growth factor receptor,cell,ErbB-1,G719X,antineoplastic,oral,NSCLC
  • Almonertinib, 10 mM in DMSO
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