NSC 663284
NSC 663284 物理性質
- 沸点 :
- 478.8±45.0 °C(Predicted)
- 比重(密度) :
- 1.41±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO: 16 mg/mL
- 外見 :
- 個体
- 酸解離定数(Pka):
- 6.79±0.10(Predicted)
- 色:
- 赤
- Sensitive :
- Light Sensitive
- 安定性：:
- 購入日から2年間安定です。この DMSO またはエタノール溶液は、-20°C で 1 か月間保存できます。
- InChI:
- 1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
- InChIKey:
- BMKPVDQDJQWBPD-UHFFFAOYSA-N
- SMILES:
- ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
NSC 663284 価格
もっと(3)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC1867 |
NSC 663284 |
383907-43-5 |
10mg |
￥90000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
N7537 |
≥98% (HPLC), solid
NSC 663284 ≥98% (HPLC), solid |
383907-43-5 |
5mg |
￥47300 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
N7537 |
≥98% (HPLC), solid
NSC 663284 ≥98% (HPLC), solid |
383907-43-5 |
25mg |
￥143000 |
2024-03-01 |
購入 |
NSC 663284 化学特性,用途語,生産方法
使用
CDC25 Phosphatase Inhibitor II, NSC 663284 is a competitive CDC25 inhibitor and cell cycle arresting compound.
一般的な説明
A cell-permable, potent, irreversible, and competitive inhibitor of the Cdc25 phosphatase family (K
i = 29 nM, 95 nM, and 89 nM for Cdc25A, Cdc25B2, and Cdc25C, respectively) with anti-proliferative properties. Displays nearly 20- and 450-fold greater selectivity over VHR and PTP1B (IC
50 = 4.0 μM and >100 μM, respectively). Reported to arrest cell cycle progression, inhibit Cdk dephosphorylation, and delay tumor growth (mean IC
50 = 1.5 μM in NCI-60 tumor cell panel). Also shown to block ERK dephosphorylation caused by ectopic Cdc25A expression.
生物活性
Potent, selective inhibitor of Cdc25 dual specificity phosphatases (K i values are 29, 95 and 89 nM for human Cdc25A, Cdc25B 2 and Cdc25C respectively); > 20- and > 450-fold selective over VHR and PTP1B phosphatases respectively. Arrests cells at both G 1 and G 2 /M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC 50 = 0.2-35 μ M).
NSC 663284 上流と下流の製品情報
原材料
準備製品
NSC 663284 生産企業
Global( 65)Suppliers
383907-43-5()キーワード:
- 383907-43-5
- CDC25 Phosphatase Inhibitor II, NSC 663284 - CAS 383907-43-5 - Calbiochem
- CDC25 Phosphatase Inhibitor II, NSC 663284
- 5,8-Quinolinedione, 6-chloro-7-[[2-(4-morpholinyl)ethyl]amino]-
- NSC 663284 (DA3003-1)
- NSC 663284 (DA3003-1), Cdc25 inhibitor
- DA-3003-1, 10 mM in DMSO