AUY922 (NVP-AUY922)
AUY922 (NVP-AUY922) 物理性質
- 融点 :
- 180-184°C
- 沸点 :
- 640.1±55.0 °C(Predicted)
- 比重(密度) :
- 1.234
- 貯蔵温度 :
- -20°C
- 溶解性:
- DMSOに可溶 (>25 mg/ml)
- 外見 :
- 個体
- 酸解離定数(Pka):
- 8.47±0.48(Predicted)
- 色:
- 白い
- 安定性：:
- -20°C の DMSO 溶液で最大 2 か月間保存できます。
- InChIKey:
- NDAZATDQFDPQBD-UHFFFAOYSA-N
- SMILES:
- O=C(C1=NOC(C2=C(O)C=C(O)C(C(C)C)=C2)=C1C3=CC=C(CN4CCOCC4)C=C3)NCC
- CAS データベース:
- 747412-49-3
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| WGK Germany |
WGK 3 |
|
|
| HSコード |
2934999090 |
|
|
| ストレージクラス |
11 - Combustible Solids |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
|
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
| H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
|
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
呼吸器への刺激のおそれ |
特定標的臓器毒性、単回暴露； 気道刺激性 |
3 |
警告 |
|
|
|
| 注意書き |
| P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
| P271 |
屋外または換気の良い場所でのみ使用すること。 |
| P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
|
AUY922 (NVP-AUY922) 価格
もっと(12)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01APOOR16660 |
5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-{4-[(morpholin-4-yl)methyl]phenyl}isoxazole-3-carboxamide |
747412-49-3 |
25mg |
￥176000 |
2018-12-26 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01APOOR16660 |
5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-{4-[(morpholin-4-yl)methyl]phenyl}isoxazole-3-carboxamide |
747412-49-3 |
100mg |
￥300300 |
2018-12-26 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCN925650 |
NVP-AUY 922 |
747412-49-3 |
10mg |
￥43800 |
2018-12-26 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01SECS1069 |
AUY922 (NVP-AUY922)
Luminespib (AUY-922, NVP-AUY922) |
747412-49-3 |
10mg |
￥74800 |
2018-12-26 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01BVI1591-1 |
NVP-AUY922 |
747412-49-3 |
1mg |
￥80600 |
2018-12-26 |
購入 |
AUY922 (NVP-AUY922) 化学特性,用途語,生産方法
溶解性
In vitro (25℃) DMSO 93 mg/mL heating (199.76 mM)
効能
抗悪性腫瘍薬, 熱ショックタンパク質阻害薬
説明
Hsp90 is a molecular chaperone of many different kinases, transcription factors, and hormone receptors involved in signal transduction, cell cycle regulation, and apoptosis. In addition to its important function in normal cell homeostasis, a high affinity form of Hsp90 is prevalent in tumor cells. Hsp90 inhibition has been associated with the degradation of oncogenic client proteins. NVP-
AUY922 is a Hsp90 inhibitor (IC
50 = 21 nM in a FP binding assay) that prevents the proliferation of a range of human cancer cell lines
in vitro with GI
50s averaging 9 nM. In a human colon cancer xenograft model, 50 mg/kg NVP-
AUY922 inhibits tumor growth by ~50% compared to vehicle controls. Unlike some first generation Hsp90 inhibitors that are quickly glucuronidated, NVP-
AUY922 is retained in tumors
in vivo when administered at 4 mg/kg i.p. by cassette dosing in tumor-
bearing mice.
定義
ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-(2,4-dihydroxy-5-isopropylphenyl)-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxylic acid with the amino group of ethylamine.
AUY922 (NVP-AUY922) 上流と下流の製品情報
原材料
準備製品
AUY922 (NVP-AUY922) 生産企業
Global( 186)Suppliers
AUY922 (NVP-AUY922) スペクトルデータ(1HNMR)
747412-49-3(AUY922 (NVP-AUY922))キーワード:
- 747412-49-3
- 5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide
- AUY922 (NVP-AUY922)
- VER 52296
- VER-52296
- AUY 922
- NVP-AUY922 (Luminespib
- CS-209
- AUY 922;AUY-922; NVP-AUY922;NVP-AUY922-NX;AUY922;VER-52296
- NVP-AUY922-NX
- NVP-AUY922 - VER 52296 | Luminespib
- AUY922 (Luminespib,NVP-AUY922)
- LUMINESPIB;NVP-AUY922;VER-52296;NVP-AUY 922;AUY-922;VER 52296;VER52296
- LuMinespib
- Luminespib (AUY-922, NVP-AUY922)
- AUY922,NVP-AUY-922,Luminespib
- 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide
- 5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide AUY922 (NVP-AUY922)
- Luminespib (NVP-AUY922)
- AUY922, VER-52296
- NVP-AUY922, >=98%
- NVP-AUY922, Luminespib, VER52296
- 5-(2,4-Dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxam
- AUY922; AUY-922; AUY 922; NVP AUY922; NVP AUY-922; VER52296 ; VER-52296 ; VER 52296 ; LUMINESPIB
- NVP-AUY922, Hsp90 Inhibitor
- 17-AAG, Hsp90 inhibitor
- 3-Isoxazolecarboxamide, 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-
- 5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide USP/EP/BP
- AUY-922 (LUMINESPIB)
- AUY-922,Luminespib,AUY 922,Inhibitor,HSP,Autophagy,Heat shock proteins,VER52296,Apoptosis,inhibit,VER 52296
- Luminespib(VER-52296
- AUY922 (NVP-AUY922)
- ルミネスピブ