Nepicastat hydrochloride
Nepicastat hydrochloride 物理性質
- 貯蔵温度 :
- Inert atmosphere,Store in freezer, under -20°C
- 溶解性:
- DMSO：可溶10mg/mL、透明
- 外見 :
- 粉
- 色:
- 白からベージュ
- InChIKey:
- DIPDUAJWNBEVOY-PPHPATTJSA-N
Nepicastat hydrochloride 価格
もっと(6)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01MAS097227 |
(S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-imidazole-2(3H)-thione hydrochloride |
170151-24-3 |
1g |
￥2163800 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML0940 |
≥95% (HPLC)
Nepicastat hydrochloride ≥95% (HPLC) |
170151-24-3 |
5mg |
￥19900 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML0940 |
≥95% (HPLC)
Nepicastat hydrochloride ≥95% (HPLC) |
170151-24-3 |
25mg |
￥64100 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01MAS097227 |
(S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-imidazole-2(3H)-thione hydrochloride |
170151-24-3 |
250mg |
￥973800 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC234881 |
(S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-imidazole-2(3H)-thione hydrochloride |
170151-24-3 |
100mg |
￥1487000 |
2018-12-26 |
購入 |
Nepicastat hydrochloride 化学特性,用途語,生産方法
説明
Nepicastat is an inhibitor of dopamine β-hydroxylase (DBH; IC
50 = 9 nM for the purified human enzyme). It is selective for DBH over a panel of 12 enzymes and 13 neurotransmitter receptors (IC
50s or K
is = >10 μM). Nepicastat dose-dependently reduces norepinephrine content and increases dopamine content in the mesenteric artery, left ventricle, and cerebral cortex in spontaneously hypertensive rats, as well as in the renal artery, left ventricle, and cerebral cortex in beagle dogs. It attenuates increases in diastolic blood pressure and heart rate induced by preganglionic sympathetic nerve stimulation in pithed spontaneously hypertensive rats when administered orally at doses of 10 and 30 mg/kg. Nepicatstat (50 mg/kg) reduces the progressive ratio response for cocaine, but not food or sucrose pellets, in rats. It also reduces reinstatement of cocaine-seeking behavior induced by cues, yohimbine , or foot-shock in rats.
使用
Nepicastat Hydrochloride is a potent and selective dopamine β-hydrolase inhibitor. Used in cardiovascular treatment where deficiencies in ventricles results in heart failure.
Nepicastat hydrochloride 上流と下流の製品情報
原材料
準備製品
Nepicastat hydrochloride 生産企業
Global( 119)Suppliers
170151-24-3()キーワード:
- 170151-24-3
- NEPICASTAT HYDROCHLORIDE
- Nepicastat HCl (SYN-117),Nepicastat hydrochloride,
- Nepicastat (SYN-117) HCl
- Nepicastat HCl (SYN-117)
- 4-(aminomethyl)-3-[(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-1H-imidazole-2-thione
- (S)-5-(AMinoMethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-iMidazole-2(3H)-thione hydrochloride
- Nepicastat (SYN117)HCI
- RS 25560-197 Nepicastat hydrochloride
- 5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione hydrochloride
- 5-(Aminomethyl)-1-[5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2(S)-yl]-2,3-dihydro-1H-imidazole-2-thione hydrochloride
- Nepicastat HCl, >=99%
- (S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-imidazole-2(3H)-thio
- Nepicastat (SYN-117) hydrochloride
- Nepicastat Hydrochloride (SYN-117 hydrochloride
- RS-25560-197 hydrochloride)
- SYN-117 HCl
- SYN-117 hydrochloride
- SYN-117 HYDROCHLORIDE;RS-25560-197 HYDROCHLORIDE
- Nepicastat hydrochloride USP/EP/BP
- 4-(aminomethyl)-3-[(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-1H-imidazole-2-thione,hydrochloride
- 2H-Imidazole-2-thione,5-(aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-,hydrochloride (1:1)
- (S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydro-2H-imidazole-2-thione hydrochloride
- Dopamine beta-monooxygenase,Dopamine beta-hydroxylase,Dopamine β-monooxygenase,Nepicastat hydrochloride,Nepicastat,SYN117,SYN-117,Dopamine β-hydroxylase,Inhibitor,SYN 117,inhibit
- Nepicastat hydrochloride, 10 mM in DMSO