HTH-01-015

1613724-42-7

CAS番号.: 1613724-42-7

化学名:: HTH-01-015

别名:: 3-[[1-(4-ピペリジニル)-1H-ピラゾール-4-イル]アミノ]-2,5,13-トリメチル-2,4,5,13-テトラアザ-1H-ベンゾ[4,5]シクロヘプタ[1,2-b]ナフタレン-12(13H)-オン;2,6,9-トリメチル-5-{[1-(ピペリジン-4-イル)-1H-ピラゾール-4-イル]アミノ}-2,4,6,9-テトラアザテトラシクロ[9.8.0.03,8.013,18]ノナデカ-1(11),3(8),4,12,14,16,18-ヘプタエン-10-オン;HTH-01-015

英語名:: HTH-01-015

英語别名:: CS-2296;HTH-01-015;HTH-01-015 >=98% (HPLC);HTH-01-015, 10 mM in DMSO;CHSDJDLAKKAWCI-UHFFFAOYSA-N;inhibit,AMPK,AMP-activated protein kinase,HTH 01 015,HTH01015,Inhibitor;5,13-Dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one;4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one;6H-Naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one, 5,13-dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-

CBNumber:: CB22715641

化学式:: C26H28N8O

分子量:: 468.55

MOL File:: 1613724-42-7.mol

物理性質

安全性情報

価格4

用途語

生産企業 93

スペクトル

HTH-01-015 物理性質

沸点 :: 759.6±70.0 °C(Predicted)

比重(密度) :: 1.41±0.1 g/cm3(Predicted)

貯蔵温度 :: -20°C

溶解性:: ≥23.45 mg/mL in DMSO; insoluble in H2O; ≥14.67 mg/mL in EtOH with ultrasonic

外見 :: 粉

酸解離定数(Pka):: 9.84±0.10(Predicted)

色:: 白から薄茶色

安全性情報

リスクと安全性に関する声明
危険有害性情報のコード(GHS)

絵表示（GHS）

注意喚起語

警告

危険有害性情報

コード	危険有害性情報	危険有害性クラス	区分	注意喚起語	P コード
H315	皮膚刺激	皮膚腐食性/刺激性	2	警告	P264, P280, P302+P352, P321,P332+P313, P362
H319	強い眼刺激	眼に対する重篤な損傷性/眼刺激性	2A	警告	P264, P280, P305+P351+P338,P337+P313P
H335	呼吸器への刺激のおそれ	特定標的臓器毒性、単回暴露；気道刺激性	3	警告

注意書き

P261	粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避けること。
P305+P351+P338	眼に入った場合：水で数分間注意深く洗うこと。次にコンタクトレンズを着用していて容易に外せる場合は外すこと。その後も洗浄を続けること。

HTH-01-015 価格もっと(4)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TOC5622	HTH 01-015	1613724-42-7	10mg	￥71000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TOC5622	HTH 01-015	1613724-42-7	50mg	￥294000	2024-03-01	購入
Sigma-Aldrich Japan	SML1446	≥98% (HPLC) HTH-01-015 ≥98% (HPLC)	1613724-42-7	5mg	￥25500	2024-03-01	購入
Sigma-Aldrich Japan	SML1446	≥98% (HPLC) HTH-01-015 ≥98% (HPLC)	1613724-42-7	25mg	￥101000	2024-03-01	購入

HTH-01-015 化学特性,用途語,生産方法

説明

NUAK1 (also known as AMPK-related kinase 5) and NUAK2 (also known as SNF1/AMPK-related kinase) are members of the AMP-activated protein kinase (AMPK) family of protein kinases that are activated by the liver kinase B1 tumor suppressor kinase. NUAK kinases are thought to have roles in regulating cell adhesion, cancer cell invasion, embryonic development, senescence, proliferation, neuronal polarity, and axon branching. HTH-01-015 is a selective inhibitor of NUAK1 (IC₅₀ = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. At 10 μM, HTH-01-015 has been shown to partially inhibit the phosphorylation of the NUAK1 substrate, myosin phosphate-targeting subunit 1 at Ser⁴⁴⁵. When administered to mouse embryonic fibroblasts in vitro, 10 μM HTH-01-015 inhibits proliferation and migration in a wound-healing assay. It has also been shown to impair the invasive potential of U2OS cells at similar concentrations in a 3D cell invasion assay.

使用

HTH 01-015 is a highly specific protein kinase inhibitor of NUAK1. It inhibits the NUAK1 phosphorylation of myosin phosphate-targeting subunit 1 (MYPT1) substrate.

Biochem/physiol Actions

HTH-01-015 is a potent and selective inhibitor of NUAK1 kinase, a member of the AMPK family that are that are activated by the LKB1 (liver kinaseB1) tumour suppressor kinase and involved in development and proliferation. HTH-01-015 has an IC50 of 100 nM for NUAK1, >100-fold higher than NUAK2, and has no significant inhibition of 139 other kinases tested, including ten AMPK-related kinase family members. Treatment with HTH-01-015 was found to suppress proliferation, restricting cells from entering into mitosis.

HTH-01-015 上流と下流の製品情報

原材料

準備製品

HTH-01-015 生産企業

Global( 93)Suppliers

名前	電話番号	電子メール	国籍	製品カタログ	優位度
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32268	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33338	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58

HTH-01-015 スペクトルデータ(¹HNMR)

HTH-01-015(1613724-42-7)¹HNMR

1613724-42-7(HTH-01-015)キーワード:

N-[4-[3-[[[5-(ジメチルアミノ)-1-ナフチル]スルホニル]アミノ]フェニル]チアゾール-2-イル]アセトアミドマリノピロールA デランゾミブシタリノスタット 5-[1-(2-ヒドロキシエチル)-3-(4-ピリジニル)-1H-ピラゾール-4-イル]インダン-1-オンオキシム 4-ヨード-3-ニトロベンズアミド

1613724-42-7
HTH-01-015
5,13-Dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one
CS-2296
CHSDJDLAKKAWCI-UHFFFAOYSA-N
6H-Naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one, 5,13-dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-
HTH-01-015 >=98% (HPLC)
inhibit,AMPK,AMP-activated protein kinase,HTH 01 015,HTH01015,Inhibitor
4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one
HTH-01-015, 10 mM in DMSO
3-[[1-(4-ピペリジニル)-1H-ピラゾール-4-イル]アミノ]-2,5,13-トリメチル-2,4,5,13-テトラアザ-1H-ベンゾ[4,5]シクロヘプタ[1,2-b]ナフタレン-12(13H)-オン
2,6,9-トリメチル-5-{[1-(ピペリジン-4-イル)-1H-ピラゾール-4-イル]アミノ}-2,4,6,9-テトラアザテトラシクロ[9.8.0.03,8.013,18]ノナデカ-1(11),3(8),4,12,14,16,18-ヘプタエン-10-オン
HTH-01-015