10-アセチルアミノ-5-メチル-6H-ジベンゾ[b,e]アゼピン-6,11(5H)-ジオン 化学特性,用途語,生産方法
Originator
Adosopine ,Menarini Group
Manufacturing Process
2 ml of acetic anhydride are added to 2.5 g of 10-amino-5,6-dihydro-11Hdibenzo[
b,e]azepine-6,11-dione (prepared from 1-aminoanthraquinone in
accordance with Caronna and Palazzo-Gaz. Chim. It. 83, 533, 1953) in 50 ml
of dioxane. After maintaining for 2 h under reflux, the mixture is evaporated
almost to dryness under reduced pressure, the residue is then poured into
water, filtered and dried to give 2.0 g of crude product.
The 2.0 g of previously obtained crude product is suspended in 20 ml of N,Ndimethylformamide,
and 710.0 mg of sodium methylate in 10 ml of methanol
are added. After maintaining for 30 min at room temperature, 2.5 ml of
methyl iodide are added, and mixture is allowed to stand for 24 h after which
the mixture is poured into water, the product filtered off, dried and crystallized
from ethanol, to give 5-methyl-10-acetamino-5,6-dihydro-11H-dibenzo[b,e]
azepine-6,11-dione, melting point 199°-201°C.
Therapeutic Function
Urinary incontinence agent
10-アセチルアミノ-5-メチル-6H-ジベンゾ[b,e]アゼピン-6,11(5H)-ジオン 上流と下流の製品情報
原材料
準備製品