AVP-AEW541
AVP-AEW541 物理性質
- 融点 :
- 145℃
- 沸点 :
- 669.0±55.0 °C(Predicted)
- 比重(密度) :
- 1.33
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- クロロホルム（微量）、メタノール（微量）
- 酸解離定数(Pka):
- 9.59±0.10(Predicted)
- 外見 :
- 粉
- 色:
- 白からベージュ
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
AVP-AEW541 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
Sigma-Aldrich Japan
|
SML1973 |
≥98% (HPLC)
NVP-AEW541 ≥98% (HPLC) |
475489-16-8 |
5mg |
￥35700 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1973 |
≥98% (HPLC)
NVP-AEW541 ≥98% (HPLC) |
475489-16-8 |
25mg |
￥112000 |
2024-03-01 |
購入 |
AVP-AEW541 化学特性,用途語,生産方法
使用
NVP-AEW541 is insulin-like growth factor I receptor (IGF-IR) inhibitor.
Biochem/physiol Actions
NVP-AEW541 is a reversible, ATP-competitive, orally available insulin-like growth factor-I receptor (IGF-IR, IGF-1R) inhibitor that, despite its equipotency against recombinant kinase domains of insulin receptor (InsR) and IGF-IR in cell-free kinase assays (IC50 = 140 & 150 nM, respectively), exhibits high selectivity toward cellular autophosphorylation of endogenous full-length IGF-1R (IC50 = 86 nM) over InsR (IC50 = 2.3 μM), HER1, PDGFR, c-Kit, and Bcr-Abl p210 (IC50 >5 μM). AEW541 effectively inhibits IGF-IR-mediated signaling and cancer survival (IC50 = 105 nM/MCF-7 soft agar growth, 1.64 μM/NWT-21 proliferation) in cultures and tumor growth in vivo (20 to 50 mg/kg twice daily p.o.; NWT-21 fibrosarcoma & TC-71 musculoskeletal sarcoma xenografts in mice).
AVP-AEW541 上流と下流の製品情報
原材料
準備製品
AVP-AEW541 生産企業
Global( 112)Suppliers
475489-16-8()キーワード:
- 475489-16-8
- NVP-AEW541,AEW541,AEW-541
- AEW541;NVP AEW541
- CS-470
- AVP-AEW541
- NVP-AEW541
- AEW-541
- NVP-AEW541(AEW541)
- [7-[cis-3-[(Azetidin-1-yl)methyl]cyclobutyl]-5-(3-benzyloxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amine
- AVP-AEW541 NVP-AEW541
- 7-((1s,3s)-3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- [7-[cis-3-[(Azetidin-1-yl)methyl]cyclobutyl]-5-(3-benzyloxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amine AVP-AEW541
- 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-
- NVP-AEW541;AEW-541;AEW541;AEW 541;NVP AEW541
- 7-((1s,3s)-3-(Azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimid
- AVP-AEW541 USP/EP/BP
- NVP-AEW541cas
- AEW-541 cis-isomer (NVP-AEW541)
- NVP-AEW541-NX
- 7-(cis-3-(Azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- NVP-AEW541, 10 mM in DMSO