ビランテロールトリフェニル酢酸塩
ビランテロールトリフェニル酢酸塩 物理性質
- 融点 :
- 131.9-134.2℃
- 貯蔵温度 :
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- 溶解性:
- ジクロロメタン（微量）、メタノール（微量）
- 外見 :
- 個体
- 色:
- ホワイトからオフホワイト
- 安定性：:
- 吸湿性
- InChIKey:
- KLOLZALDXGTNQE-NETKZVBLNA-N
- SMILES:
- C(C1C=CC=CC=1)(C1C=CC=CC=1)(C1C=CC=CC=1)C(=O)O.[C@H](C1C=CC(O)=C(CO)C=1)(O)CNCCCCCCOCCOCC1C(=CC=CC=1Cl)Cl |&1:22,r|
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
ビランテロールトリフェニル酢酸塩 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
Sigma-Aldrich Japan
|
SML3389 |
≥95% (HPLC)
Vilanterol trifenatate ≥95% (HPLC) |
503070-58-4 |
10MG |
￥8210 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML3389 |
≥95% (HPLC)
Vilanterol trifenatate ≥95% (HPLC) |
503070-58-4 |
50MG |
￥33100 |
2024-03-01 |
購入 |
ビランテロールトリフェニル酢酸塩 化学特性,用途語,生産方法
効能
気管支拡張薬, β2アドレナリン受容体作動薬
化学的特性
Vilanterol trifenatate is a white powder with a molecular weight of 774.8, and the empirical formula is C24H33Cl2NO5.C20H16O2. It insoluble in water and slightly soluble in methanol, ethanol, acetonitrile and propan-2-ol. It is slightly hygroscopic. It is provided in a micronized form.
使用
Vilanterol Trifenatate is a long-acting β2 adrenergic receptor Agonist with alonger than 24-hour activity in humans, and is being developed to be used in combination with FF. It is also highly selective for the β2-receptor, with over 1000-fold greater selectivity compared to β1-receptors. It demonstrates prolonged bronchodilation in subjects with asthma and COPD.
定義
ChEBI: Vilanterol Trifenatate is a triphenylacetate salt obtained by combining vilanterol with one equivalent of triphenylacetic acid. Used in combination with fluticasone furoate for treatment of bronchospasm associated with chronic obstructive pulmonary disease. It has a role as a beta-adrenergic agonist and a bronchodilator agent. It contains a vilanterol(1+).
製造方法
Vilanterol trifenatate is synthesized by incorporation of an oxygen atom at the homobenzylic position of the right-hand side phenyl ring of (R)-salmeterol and has suitable chemical properties for inhaled administration. The combination in fluticasone furoate (FF) and vilanterol trifenatate (VI) in a single inhaler is the first once daily combination available on the market for the treatment of stable COPD.
Dosage
The recommended and maximum dose is one inhalation of vilanterol trifenatate 25 micrograms once daily either morning or evening but at the same time every day.
Mode of action
Vilanterol Trifenatate is a selective long-acting beta2-receptor agonist (also referred to as a LABA). The pharmacologic effects of beta2-adrenoceptor agonist drugs, including vilanterol trifenatate, are at least in part attributable to stimulation of intracellular adenylate cyclase, the enzyme that catalyses the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cyclic AMP). Increased cyclic AMP levels cause relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
ビランテロールトリフェニル酢酸塩 上流と下流の製品情報
原材料
4H-1,3-Benzodioxin, 6-[(1R)-2-bromo-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,2-dimethyl-
(1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]aMino]-1-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)ethanol
2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
(5R)-5-(2,2-ジメチル-4H-1,3-ベンゾジオキシン-6-イル)-1,3-オキサゾリジン-2-オン
ビランテロール
トリフェニル酢酸
準備製品
ビランテロールトリフェニル酢酸塩 生産企業
Global( 197)Suppliers
ビランテロールトリフェニル酢酸塩 スペクトルデータ(1HNMR)
503070-58-4(ビランテロールトリフェニル酢酸塩)キーワード:
- 503070-58-4
- Vilanterol triphenylacetate
- GW642444M; GW 642444M; GW-642444M
- Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1:1)
- vilanterol trifenatate
- GW 642444M
- GW642444M
- GW-642444M
- Vilanterol Trifenatate (API)
- 4-[(R)-2-[[6-[2-(2,6-Dichlorobenzyloxy)ethoxy]hexyl]amino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol triphenylacetate
- Vilanterol Trifenate
- Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-6-2-(2,6-dichlorophenyl)MethoxyethoxyhexylaMinoMethyl-4-hydroxy-1,3-benzenediMethanol (1
- GW642444 (trifenatate)
- (R)-4-(2-((6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)amino)-1-hydroxyethyl)-2-(hydroxymethyl)phenyl 2,2,2-triphenylacetate
- Pharmaceuticals Chemical Vilanterol Trifenatate Powder
- Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1
- GW642444M Trifenate
- (R)-4-(2-((6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)amino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol2,2,2-triphenylacetate
- Vilanterol TrifenatateQ: What is
Vilanterol Trifenatate Q: What is the CAS Number of
Vilanterol Trifenatate Q: What is the storage condition of
Vilanterol Trifenatate Q: What are the applications of
Vilanterol Trifenatate
- 503070-58-4 Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1:1)
- VilanterolImpurity8Triphenylacetate
- 1-(3-(6-((pyridin-3-ylmethyl)amino)-1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl)ethan-1-ol
- Vilanterol Trenearate
- ビランテロールトリフェニル酢酸塩
- ビランテロールトリフェナテート
- ビランテロールトリフェニル酢酸塩 (JAN)