1-メチルピペリジン 化学特性,用途語,生産方法
外観
無色～うすい黄褐色, 澄明の液体
溶解性
水及びエタノールに極めて溶けやすい。
用途
有機合成原料。
用途
綿の木の生長調整物質の製造
使用上の注意
不活性ガス封入
説明
This simple piperidine derivative has been obtained from Girgensohnia diptera Bge. It is optically inactive and furnishes a crystalline picrate, m.p. 15 I-2°C and a picrolonate, m.p. 226°C.
化学的特性
CLEAR COLOURLESS LIQUID
使用
Reactant for:
·sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines
·One-pot synthesis of Z-cinnamic acids
Reactant for synthesis of:
·Unsymmetrical ureas
·Antibacterial imidazolium, pyrrolidinium, and piperidinium salts
·C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling
·Multi-targeted inhibitors of insulin-like growth factor-1 receptor and members of ErbB-family receptor kinases
一般的な説明
A colorless liquid with the odor of pepper. Density 0.816 g / cm3 and flash point 38°F. May irritate skin and eyes. Vapors heavier than air. Used as a solvent and to make other chemicals.
空気と水の反応
Highly flammable. Soluble in water.
反応プロフィール
N-Methylpiperidine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
健康ハザード
May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
火災危険
Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
安全性プロファイル
Poison by
intraperitoneal and subcutaneous routes. A very dangerous fire hazard when exposed to
heat or flame. When heated to
decomposition it emits toxic fumes of NOx.
参考文献
Jurashevskii, Stepanov,J. Gen. Chem. USSR, 9,2203 (1939)
1-メチルピペリジン 上流と下流の製品情報
原材料
準備製品