2-[2-[[4-(ジフェニルメチル)ピペラジノ]カルボニルメトキシ]アセチルアミノ]-5-クロロ安息香酸ナトリウム
2-[2-[[4-(ジフェニルメチル)ピペラジノ]カルボニルメトキシ]アセチルアミノ]-5-クロロ安息香酸ナトリウム 物理性質
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO:20.0(Max Conc. mg/mL);36.77(Max Conc. mM)
DMF:PBS (pH 7.2) (1:8):0.11(Max Conc. mg/mL);0.2(Max Conc. mM)
DMF:33.0(Max Conc. mg/mL);60.66(Max Conc. mM)
- 外見 :
- 粉
- 色:
- 白からベージュ
2-[2-[[4-(ジフェニルメチル)ピペラジノ]カルボニルメトキシ]アセチルアミノ]-5-クロロ安息香酸ナトリウム 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
Sigma-Aldrich Japan
|
SML1398 |
≥98% (HPLC)
TM5275 sodium salt ≥98% (HPLC) |
1103926-82-4 |
5mg |
￥42300 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1398 |
≥98% (HPLC)
TM5275 sodium salt ≥98% (HPLC) |
1103926-82-4 |
25mg |
￥123000 |
2024-03-01 |
購入 |
2-[2-[[4-(ジフェニルメチル)ピペラジノ]カルボニルメトキシ]アセチルアミノ]-5-クロロ安息香酸ナトリウム 化学特性,用途語,生産方法
説明
TM5275 is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC
50 = 6.95 μM), a serine-protease inhibitor involved in thrombosis. TM5275 inhibits formation of a complex consisting of tissue plasminogen activator (tPA), PAI-1, and GFP on vascular endothelial cells (VECs)
in vitro, prolonging the time that tPA is retained on VECs. It also enhances fibrin clot dissolution and plasminogen accumulation
in vitro and has antithrombotic effects in rat models of thrombosis. TM5275 (10 and 50 mg/kg) decreases blood clot weight in an arteriovenous shunt thrombosis model and increases the time to primary occlusion in a ferric chloride-treated carotid artery thrombosis model when used at doses of 1 and 3 mg/kg. In a cynomolgus monkey model of photochemical-induced arterial thrombosis, TM5275 (10 mg/kg) increases the time to primary occlusion. It does not affect platelet activity, activated partial thromboplastin time, prothrombin time, or prolong bleeding time.
使用
TM 5275 Sodium Salt is a novel inhibitor of plasminogen activator inhibitor-1 (PAI-1), which provides antithrombitic benefits devoid of bleeding in primates.
Biochem/physiol Actions
TMS5275 is an orally available, potent and selective inhibitor of PAI-1 that delivers antithrombotic benefits devoid of bleeding effect in nonhuman primates.
2-[2-[[4-(ジフェニルメチル)ピペラジノ]カルボニルメトキシ]アセチルアミノ]-5-クロロ安息香酸ナトリウム 上流と下流の製品情報
原材料
準備製品
2-[2-[[4-(ジフェニルメチル)ピペラジノ]カルボニルメトキシ]アセチルアミノ]-5-クロロ安息香酸ナトリウム 生産企業
Global( 76)Suppliers
- 1103926-82-4
- TM 5275
- TM 5275 sodium salt
- TM5275 (sodium)
- CS-2524
- TM 5275;TM-5275
- 2-(2-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy)acetamido)-5-chlorobenzoic acid sodium salt
- 5-Chloro-2-[[2-[2-[4-(Diphenylmethyl)-1-piperazinyl]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt
- TM5275 sodium salt >=98% (HPLC)
- TM5275 Na
- Plasminogen activator inhibitor-1,PAI-1,TM5275,TM5275 sodium,TM-5275 sodium,TM-5275,inhibit,TM 5275,Inhibitor
- Sodium 2-(2-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy)acetamido)-5-chlorobenzoate
- TM5275 sodium, 10 mM in DMSO
- 2-[2-[[4-(ジフェニルメチル)ピペラジノ]カルボニルメトキシ]アセチルアミノ]-5-クロロ安息香酸ナトリウム
- ナトリウム 5-クロロ-2-(2-{2-[4-(ジフェニルメチル)ピペラジン-1-イル]-2-オキソエトキシ}アセトアミド)ベンゾアート