SI-2
SI-2 物理性質
- 沸点 :
- 459.9±37.0 °C(Predicted)
- 比重(密度) :
- 1.22±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO に可溶 (最大 20 mg/ml)。
- 外見 :
- 個体
- 酸解離定数(Pka):
- 11.05±0.70(Predicted)
- 色:
- ペールオレンジ
- 安定性：:
- -20°C の DMSO 溶液で最大 1 か月間保存できます。
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
SI-2 価格
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製品番号 |
製品説明 |
CAS番号 |
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SI-2 化学特性,用途語,生産方法
使用
SI-2 is an inhibitor of steroid receptor coactivator-3 (SRC-3). Induces cell death in verious breast cancer cells.
Biochem/physiol Actions
SI-2 targets the receptor-interacting domain (RID) of steroid receptor coactivators (SRCs) and suppresses cellular transcriptional activity (Effec. conc. >/= 5 nM in cell-based SRC-1, SRC-2, and SRC-3 reporter assays) by downregulating SRCs protein, but not transcript level (Effec. conc. >/= 12.5 nM against SRC-3, >/= 25 nM against SRC-1 and SCR-2 in MDA-MB-468 culture). SI-2 is cytotoxic to breast cancer cultures (IC50?= 1.5 nM/BT-474, 3.4 nM/MDA-MB-468, 22 nM/MCF-7), but not to normal hepatocytes even at 500 nM concentration. SI-2 is reported to be orally available in mice and, when administered intraperitoneally (2 mg/kg b.i.d.), effectively suppress MDA-MB-468-derived tumor expansion in mice?in vivowith good pharmacokinetics (Cmax?= 30 μM,?tmax?= 0.25 h,?t1/2?= 1.0 h; 20 mg/kg i.p.) and no apparent adverse effects to the animals.
SI-2 上流と下流の製品情報
原材料
準備製品
SI-2 生産企業
Global( 32)Suppliers
380537-35-9()キーワード:
- 380537-35-9
- SI-2
- Ethanone, 1-(2-pyridinyl)-, 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone, (1E)-
- 1-(2-pyridinyl)-, 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone, (1E)-
- (E)-SI-2
- (E)SI2,(E) SI 2
- (E)-SI-2, 10 mM in DMSO
- 1-Methyl-N-[(E)-1-pyridin-2-ylethylideneamino]benzimidazol-2-amine