オマダサイクリン
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- CAS番号.
- 389139-89-3
- 化学名:
- オマダサイクリン
- 别名:
- オマダサイクリン;アマダサイクリン;(4S,4aS,5aR,12aS)-4,7-ビス(ジメチルアミノ)-9-[[(2,2-ジメチルプロピル)アミノ]メチル]-1,4,4a,5,5a,6,11,12a-オクタヒドロ-3,10,12,12a-テトラヒドロキシ-1,11-ジオキソ-2-ナフタセンカルボアミド;(4S,4aS,5aR,12aS)-4,7-ビス(ジメチルアミノ)-9-{[(2,2-ジメチルプロピル)アミノ]メチル}-3,10,12,12a-テトラヒドロキシ-1,11-ジオキソ-1,4,4a,5,5a,6,11,12a-オクタヒドロテトラセン-2-カルボキサミド;6-デオキシ-6-デメチル-7-(ジメチルアミノ)-9-(2,2-ジメチルプロピルアミノメチル)テトラサイクリン
- 英語名:
- Omadacycline
- 英語别名:
- OMadacycline;AMadacycline;PTK-796;PTK 0796;Omadacycline-D9;2H9]-Omadacycline;Omadacycline (PTK 0796;Omadacycline, 10 mM in DMSO;Amadacycline，Omadacycline，PTK 0796;OMADACYCLINE; PTK 0796; PTK-0796; PTK0796; AMADACYCLINE
- CBNumber:
- CB42627315
- 化学式:
- C29H40N4O7
- 分子量:
- 556.65
- MOL File:
- 389139-89-3.mol
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オマダサイクリン 物理性質
- 沸点 :
- 837.6±65.0 °C(Predicted)
- 比重(密度) :
- 1.39±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- Store at -20°C
- 溶解性:
- DMSO:1.0(Max Conc. mg/mL);1.8(Max Conc. mM)
- 外見 :
- A crystalline solid
- 酸解離定数(Pka):
- 4.50±1.00(Predicted)
- 色:
- Yellow to orange
- 安定性：:
- Hygroscopic
- InChIKey:
- JEECQCWWSTZDCK-IQZGDKDPSA-N
- SMILES:
- C1(=O)[C@]2(O)[C@@]([H])(C[C@@]3([H])C(=C2O)C(=O)C2=C(C(N(C)C)=CC(CNCC(C)(C)C)=C2O)C3)[C@H](N(C)C)C(O)=C1C(N)=O
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
オマダサイクリン 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
オマダサイクリン 化学特性,用途語,生産方法
効能
抗生物質, タンパク質合成阻害薬
説明
Omadacycline, the drug that US FDA approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. It is not susceptible to common tetracycline-resistancemechanisms, and has demonstrated efficacy against a broad spectrum of pathogens including resistant isolates, which are increasing in prevalence and complexity.
使用
Omadacycline is a potent an demonstrates efficacy against both Bacillus anthracis and Yersinia pestis; Also, it is a novel aminomethylcycline antibiotic in clinical development for community-acquired bacterial pneumonia (CABP).
薬理学
Omadacycline has shown clinical efficacy in anaerobic acute bacterial skin and skin structure infections (ABSSSI) and in animal models of intra-abdominal anaerobic infections.The in vitro activity of Omadacycline against clinically relevant anaerobes was similar to that of tigecycline, with MIC90 values of 1 to 8 g/ml against Bacteroides spp, 0.5 g/ml against Clostridium difficile, Prevotella spp., and Porphyromonas asaccharolytica,1 g/ml against Peptostreptococcus spp, and 16 g/ml against Clostridium perfringens.
副作用
OMadacycline may cause serious adverse reactions including hypersensitivity reactions, tooth discoloration,Clostridioides difficile-associated diarrhea, and reversible inhibition of bone growth when administered during the second and third trimesters of pregnancy.Common adverse reactions include nausea, vomiting, infusion site reactions, alanine aminotransferase increased, aspartate aminotransferase increased, gamma-glutamyl transferase increased, hypertension, headache, diarrhea, insomnia, and constipation.Mild to moderate nausea and vomiting were the most frequent treatment-emergent adverse events in omadacycline (111 [30%] of 368 and 62 [17%] of 368, respectively) groups.
オマダサイクリン 上流と下流の製品情報
原材料
準備製品
オマダサイクリン 生産企業
Global( 104)Suppliers
389139-89-3(オマダサイクリン)キーワード:
- 389139-89-3
- AMadacycline
- OMadacycline
- PTK 0796
- PTK-796
- OMADACYCLINE; PTK 0796; PTK-0796; PTK0796; AMADACYCLINE
- 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[(2,2-dimethylpropyl)amino]methyl]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-
- Omadacycline-D9
- Amadacycline，Omadacycline，PTK 0796
- 2H9]-Omadacycline
- Omadacycline (PTK 0796
- spectrum,antibacterial,pathogens,Omadacycline,synthesis,Inhibitor,urinary,community-acquired,PTK-0796,skin-structure,anaerobic,acute,protein,pneumonia,tetracycline,inhibit,skin,Gram-negative,atypical,Antibiotic,Gram-positive,tract,PTK0796,broad,Bacterial,infections,agent
- (4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-((neopentylamino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
- Omadacycline, 10 mM in DMSO
- オマダサイクリン
- アマダサイクリン
- (4S,4aS,5aR,12aS)-4,7-ビス(ジメチルアミノ)-9-[[(2,2-ジメチルプロピル)アミノ]メチル]-1,4,4a,5,5a,6,11,12a-オクタヒドロ-3,10,12,12a-テトラヒドロキシ-1,11-ジオキソ-2-ナフタセンカルボアミド
- (4S,4aS,5aR,12aS)-4,7-ビス(ジメチルアミノ)-9-{[(2,2-ジメチルプロピル)アミノ]メチル}-3,10,12,12a-テトラヒドロキシ-1,11-ジオキソ-1,4,4a,5,5a,6,11,12a-オクタヒドロテトラセン-2-カルボキサミド
- 6-デオキシ-6-デメチル-7-(ジメチルアミノ)-9-(2,2-ジメチルプロピルアミノメチル)テトラサイクリン