レチノール酢酸エステル 化学特性,用途語,生産方法
外観
わずかにうすい黄色～黄赤色、結晶性粉末～粉末わずかにうすい黄色～黄赤色, 結晶性粉末～粉末
定義
本品は、酢酸(*)とレチノール(*)のエステルである。
参照表示名称：酢酸, レチノール
溶解性
2-プロパノール溶状：本品50mg+2-プロパノール(→200ml)……澄明
無機性値/有機性値
80/420
化粧品の成分用途
皮膚コンディショニング剤
効能
抗ニキビ薬, ビタミンA補充薬, レチノイン酸受容体(RAR)作動薬
使用上の注意
不活性ガス封入
説明
Retinyl acetate (retinol acetate, vitamin A acetate,127-47-9) is a natural form of vitamin A. It is the acetate ester of retinol. It consists of yellow crystals which are greasy or sticky. It has a mild, characteristic odor. It has potential antineoplastic and chemo-preventive activities. It can be used to fortify food with vitamin A. As vitamin A acetate can induce cell differentiation and inhibit cell proliferation, it is used in skin-conditioning agent.
化学的特性
Retinyl acetate is a yellow, prism-shaped crystal and a lipid-soluble compound, with better chemical stability than vitamin A. In clinical practice, either vitamin A acetate or its palmitate form is typically dissolved in vegetable oil for administration, where it is hydrolyzed by enzymes in the body to release active vitamin A. The form of vitamin A listed in the Chinese Pharmacopoeia refers to the active vitamin A compound.
使用
Retinyl acetate has been used:
- a control diet to study its effect at different developmental periods in fish larvae
- to study its inhibitory effects on Mycobacterium aviumsubspeciesparatuberculosis(MAP) strains
- as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk
製造方法
A method for preparing retinyl acetate the following steps:
Under alkaline conditions, 3-methyl-4-oxo-2-butene-1-yl acetate (referred to as C5 aldehyde ester) and tetraethyl methylene diphosphate undergo a condensation reaction to form an intermediate C6 phosphate (chemical name: 5-(diethyl phosphate)-3-methyl-2,4-hexadiene-1-acetate).
Under alkaline conditions, the C6 phosphate undergoes a transposition reaction. C14 aldehyde (chemical name: 2-methyl-4-(2,6,6-trimethyl-1-cyclohexene-1-yl)-3-butene-1-aldehyde) is then added to undergo a Wittig-Horner condensation reaction, yielding retinyl acetate.
一般的な説明
Retinyl acetate is suitable for use in the retention identification of the analyte when using HPLC and GC. Not intended for use as an activity reference standard. It has been thoroughly evaluated to ensure the utmost quality. Neat, unless otherwise noted. Certificate of Composition provided with the purchase.
安全性プロファイル
Moderately toxic by
ingestion. Experimental teratogenic and
reproductive effects. Questionable
carcinogen with experimental neoplastigenic
data. Mutation data reported. When heated
to decomposition it emits acrid smoke and
irritating fumes. See also VITAMIN A.
純化方法
The acetate is separated from retinol by column chromatography, then crystallised from MeOH. [Kofler and Rubin Vitamins and Hormones (NY) 18 315 1960 for purification methods]. Store it in the dark, under N2 or Ar, at 0o. [Beilstein 6 IV 4135.]
レチノール酢酸エステル 上流と下流の製品情報
原材料
準備製品