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POMALIDOMIDE-PEG2-CO2H

化学構造式
2140807-17-4
CAS番号.
2140807-17-4
化学名:
别名:
英語名:
POMALIDOMIDE-PEG2-CO2H
英語别名:
Poma-PEG2-COOH;Pomalidomide-PEG2-COOH;NUN 07174;Pomalidomide-PEG2-Acid;POMALIDOMIDE-PEG2-CO2H;Pomalidomide 4'-PEG2-acid;Thalidomide-4-NH-PEG2-COOH;Thalidomide-NH-PEG2-C2-COOH;Pomalidomide-PEG2-CO2H >=98%;Thalidomide-4-NH-PEG2-C2-COOH
CBNumber:
CB44744117
化学式:
C20H23N3O8
分子量:
433.41
MOL File:
2140807-17-4.mol
MSDS File:
SDS

POMALIDOMIDE-PEG2-CO2H 物理性質

沸点 :
744.6±60.0 °C(Predicted)
比重(密度) :
1.456±0.06 g/cm3(Predicted)
貯蔵温度 :
2-8°C
外見 :
粉末または結晶
酸解離定数(Pka):
4.28±0.10(Predicted)
色:
White to yellow
InChI:
1S/C20H23N3O8/c24-15-5-4-14(18(27)22-15)23-19(28)12-2-1-3-13(17(12)20(23)29)21-7-9-31-11-10-30-8-6-16(25)26/h1-3,14,21H,4-11H2,(H,25,26)(H,22,24,27)
InChIKey:
NKISJPXMSOQWER-UHFFFAOYSA-N
SMILES:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCOCCC(O)=O)=O)NC1=O

安全性情報

WGK Germany  WGK 3
ストレージクラス 11 - Combustible Solids

POMALIDOMIDE-PEG2-CO2H 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

POMALIDOMIDE-PEG2-CO2H 化学特性,用途語,生産方法

使用

Protein degrader builiding block Pomalidomide-PEG2-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

POMALIDOMIDE-PEG2-CO2H 上流と下流の製品情報

原材料

準備製品

POMALIDOMIDE-PEG2-CO2H 生産企業

Global( 65)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000
 marketing@targetmol.com United States 32431 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +86-15965530500
 nickzhang@hangyubiotech.com China 9930 58
Zhengzhou Lingzhiyue Technology Co., Ltd 		+86-0371-55074660 +86-13523716970
 Lingzhiyue@aliyun.com China 3137 58
Xian confluore Biological Technology Co., Ltd. 		+86-15680926068
1924344760@confluore.cn China 3000 58
Aladdin Scientific
tp@aladdinsci.com United States 54746 58
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865
 han_yajun@dctc.daicel.com China 7910 65
ChemShuttle, Inc. 0510-83588313-811 18800520310
 sales@chemshuttle.com China 2999 62
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860
 anhua.mao@aladdin-e.com China 29988 65
Bide Pharmatech Ltd. 400-164-7117 18317119277
 product02@bidepharm.com China 40000 60
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51389 80

  スペクトルデータ(1HNMR)

POMALIDOMIDE-PEG2-CO2H(2140807-17-4)1HNMR
  • 2140807-17-4
  • POMALIDOMIDE-PEG2-CO2H
  • Pomalidomide-PEG2-CO2H >=98%
  • NUN 07174
  • Thalidomide-4-NH-PEG2-COOH
  • Thalidomide-NH-PEG2-C2-COOH
  • Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]-
  • 3-[2-[2-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]ethoxy]ethoxy]propanoic Acid
  • Thalidomide-4-NH-PEG2-C2-COOH
  • 3-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]propanoic Acid
  • Pomalidomide-PEG2-Acid
  • 3-[2-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)ethoxy]propanoic acid
  • Pomalidomide 4'-PEG2-acid
  • Pomalidomide-PEG2-CO2H
  • Pomalidomide-PEG2-COOH
  • Poma-PEG2-COOH
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