ピルフェニドン
ピルフェニドン 物理性質
- 融点 :
- 96-97°C
- 沸点 :
- 329.1±15.0 °C(Predicted)
- 比重(密度) :
- 1.137±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Sealed in dry,Room Temperature
- 溶解性:
- DMSO: ≥10 mg/mL、可溶
- 外見 :
- 個体
- 酸解離定数(Pka):
- -0.16±0.63(Predicted)
- 色:
- オフホワイト
- 水溶解度 :
- Soluble to 20 mM in water
- 安定性：:
- -20°C の DMSO 溶液で最大 1 か月間保存できます。
- InChI:
- InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
- InChIKey:
- ISWRGOKTTBVCFA-UHFFFAOYSA-N
- SMILES:
- C1(=O)N(C2=CC=CC=C2)C=C(C)C=C1
- CAS データベース:
- 53179-13-8(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
|
| 注意書き |
|
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBOR-2236 |
ピルフェニドン
Pirfenidone |
53179-13-8 |
1g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBOR-2236 |
ピルフェニドン
Pirfenidone |
53179-13-8 |
5g |
￥30000 |
2024-03-01 |
購入 |
|
東京化成工業
|
P1871 |
ピルフェニドン >98.0%(GC)
Pirfenidone
>98.0%(GC) |
53179-13-8 |
100mg |
￥6000 |
2024-03-01 |
購入 |
|
東京化成工業
|
P1871 |
ピルフェニドン >98.0%(GC)
Pirfenidone
>98.0%(GC) |
53179-13-8 |
1g |
￥31100 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
46472-1A |
Pirfenidone |
53179-13-8 |
1g |
￥66550 |
2024-07-01 |
購入 |
ピルフェニドン 化学特性,用途語,生産方法
外観
白色～うすい黄色～緑色粉末～結晶
効能
鎮痛薬, 抗線維化薬, 抗炎症薬, 解熱薬
商品名
ピレスパ (塩野義製薬)
説明
Until recently, IPF therapy consisted of a combination of corticosteroids
and immunosuppressive agents (azathioprine and cyclophosphamide)
to target the inflammation that was believed to be the pathogenic
stimulus.Since IPF is now considered to be predominantly a disorder of
fibroproliferation, agents that intervene in fibrogenesis have moved
to the forefront of treatment options. With demonstrated efficacy in a
bleomycin-induced lung fibrosis animal model, pirfenidone has been
developed and launched as an approved therapy for IPF. Its antifibrotic activity is derived from the inhibition of p38 MAP kinase that is
upstream of transforming growth factor-β (TGF-β), a cytokine implicated
in the stimulation of collagen synthesis and the inhibition of its
degradation. Pirfenidone also inhibits the expression of TNF-α, IL-1,
and ICAM-1, so it possesses the dual benefit of an anti-inflammatory and
antifibrotic agent. This relatively simplistic drug is constructed by the copper-catalyzed reaction of 5-methyl-2(1H)-pyridinone with bromo- or chlorobenzene.
.
化学的特性
Off-White Solid
使用
Pirfenidone is in a group of medicines called antifibrotic agents. Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver. It affects your body’s immune system and reduces the amount of fibrosis (scarring) in the lungs. Pirfenidone is one of two medicines that are approved in Canada to treat Idiopathic Pulmonary Fibrosis (IPF). Another name for this medicine is Esbriet.
定義
ChEBI: A pyridone that is 2-pyridone substituted at positions 1 and 5 by phenyl and methyl groups respectively. An anti-inflammatory drug used for the treatment of idiopathic pulmonary fibrosis.
一般的な説明
Pirfenidone?(5-methyl-1-phenyl-2-[1H]-pyridone) is a synthetic derivative of pyridine.
生物活性
Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo . Potent scavenger of free radicals and inhibitor of lipid peroxidation.
ピルフェニドン 上流と下流の製品情報
原材料
準備製品
ピルフェニドン 生産企業
Global( 642)Suppliers
53179-13-8(ピルフェニドン)キーワード:
- 53179-13-8
- 5-Methyl-1-phenylpyridine-2(1H)-one
- S-7701
- 5-methyl-1-phenyl-2-pyridone
- 5-methyl-1-phenyl-pyridin-2-one
- 5-methyl-1-phenylpyridin-2-one
- Pirfenidone, >=99%
- 5-methyl-1-phenylpyridin-2(1H)-one
- Pirfenidone(S-7701,AMR-69)
- 2(1H)-Pyridinone,5-Methyl-1-phenyl-
- Pirfenidone ( 5-Methyl-1-Phenyl-2(1H)-Pyridinone)
- Pirfenidone SynonyMs 5-Methyl-1-phenyl-2-(1H)-pyridone
- S-7701,AMR-69
- Pirespa
- 5-methyl-1-phenyl-2(1h)-pyridon
- amr-69
- PIRFENIDONE
- 5-METHYL-1-PHENYL-1H-PYRIDIN-2-ONE
- 5-METHYL-1-PHENYL-2(1H)-PYRIDINONE
- 5-METHYL-1-PHENYL-2-(1H)-PYRIDONE
- 5-Methyl-N-phenyl-2-1H-pyridone
- Pirfenidone also see 5-Methyl-1-Phenyl-2(1H)-Pyridinone
- TORASEMIDETECHPIRFENIDONE
- 5-Methyl-N-phenyl-2-1H-pyridone [Pirfenidone]
- Pirfenidone(AMR-69)
- Pirfenidone, 98%, an inhibitor for TGF-β production and TGF-β stimulated collagen
- pirfenidone price
- 5-Methyl-1-phenyl-2-pyridinone
- Pirfenidone CRS
- Pirfenidone>
- Pirfenidone USP/EP/BP
- パーフェニドン
- 5-メチル-1-フェニル-2(1H)-ピリドン
- 5-メチル-1-フェニルピリジン-2(1H)-オン
- ピルフェニドン
- 5-メチル-1-フェニル-2-ピリドン
- 5-メチル-N-フェニル-2-1H-ピリドン[ピルフェニドン]
- ピルフェニドン (JAN)
- ピレスパ
- 1-フェニル-5-メチルピリジン-2-オン
- 5-メチル-1-フェニル-1,2-ジヒドロピリジン-2-オン