Cyhalodiamide 化学特性,用途語,生産方法
使用
Cyhalodiamide is a diamide insecticide and an agrochemical compound.
合成
Starting from 2-chlorophthalic anhydride, the 1-position amidation reaction is carried out with 4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-2-methylaniline in dichloromethane at 25°C for 6 hours, catalyzed by triethylamine, to obtain the monoamide intermediate; subsequently, this intermediate undergoes 2-position amidation with 2-amino-2-methylpropanenitrile in N,N-dimethylformamide (DMF), using triphosgene as the condensing agent, at 60°C for 12 hours; after the reaction, the reaction mixture is washed with water, concentrated under reduced pressure, and purified by recrystallization from an ethanol-water mixture (volume ratio 3:1), yielding Cyhalodiamide with a melting point of 216–218°C, a purity of 98.5%, and an overall yield of 78%.
Cyhalodiamide 上流と下流の製品情報
原材料
準備製品