Ganirelix Acetate 化学特性,用途語,生産方法
Originator
Antagon,Organon
Therapeutic Function
LHRH antagonist
臨床応用
Ganirelix acetate is an analog of GnRH with substitutions at residues 1, 2, 3, 6, 8, and 10. It is not a superagonist but, rather, is a synthetic decapeptide with high antagonist
activity and the first GnRH antagonist to be marketed. It is approved for the suppression of LH
surges in women who are undergoing ovarian hyperstimulation fertility treatment; LH surges
normally promote ovulation. The goal of this drug is to significantly reduce the number of
medication days necessary to suppress the LH surge, thereby maintaining eggs in the ovaries.
In vitro fertilization (IVF) treatment cycles were historically initiated by the administration of
leuprolide acetate to suppress the premature release of LH. This inhibits ovulation so that the
eggs remain available for retrieval by a fertility specialist. For this purpose, leuprolide acetate usually is injected for as many as 26 days. Clinical studies have shown that ganirelix acetate
can shut down the LH surge in only 5 days of treatment, that the suppression of LH is more
pronounced than that of FSH, and that the shorter treatment time minimizes unpleasant side
effects, such as hot flashes and headaches.
Ganirelix Acetate 上流と下流の製品情報
原材料
準備製品