4-ヒドロキシフェニル酢酸
4-ヒドロキシフェニル酢酸 物理性質
- 融点 :
- 148-151 °C(lit.)
- 沸点 :
- 234.6°C (rough estimate)
- 比重(密度) :
- 1.2143 (rough estimate)
- 蒸気圧:
- 0.007Pa at 25℃
- 屈折率 :
- 1.4945 (estimate)
- 貯蔵温度 :
- Inert atmosphere,Room Temperature
- 溶解性:
- 50g/リットル
- 酸解離定数(Pka):
- 4.50±0.10(Predicted)
- 外見 :
- 結晶性粉末
- 色:
- 白からクリーム色または薄い黄褐色
- PH:
- 2.0-2.4 (30g/l, H2O, 20℃)
- 水溶解度 :
- ジメチルスルホキシド、メタノールに可溶。水にわずかに溶ける。
- BRN :
- 1448766
- InChI:
- 1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)
- InChIKey:
- XQXPVVBIMDBYFF-UHFFFAOYSA-N
- SMILES:
- OC(=O)Cc1ccc(O)cc1
- LogP:
- 0.75 at 25℃
- CAS データベース:
- 156-38-7(CAS DataBase Reference)
- NISTの化学物質情報:
- Benzeneacetic acid, 4-hydroxy-(156-38-7)
- EPAの化学物質情報:
- Benzeneacetic acid, 4-hydroxy- (156-38-7)
4-ヒドロキシフェニル酢酸 価格
もっと(32)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01AFAA15018 |
4-ヒドロキシフェニル酢酸, 99%
4-Hydroxyphenylacetic acid, 99% |
156-38-7 |
25g |
￥14410 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01AFAA15018 |
4-ヒドロキシフェニル酢酸, 99%
4-Hydroxyphenylacetic acid, 99% |
156-38-7 |
100g |
￥37950 |
2024-03-01 |
購入 |
|
東京化成工業
|
H0290 |
4-ヒドロキシフェニル酢酸 >99.0%(GC)(T)
4-Hydroxyphenylacetic Acid
>99.0%(GC)(T) |
156-38-7 |
25g |
￥4600 |
2024-03-01 |
購入 |
|
東京化成工業
|
H0290 |
4-ヒドロキシフェニル酢酸 >99.0%(GC)(T)
4-Hydroxyphenylacetic Acid
>99.0%(GC)(T) |
156-38-7 |
100g |
￥10600 |
2024-03-01 |
購入 |
|
関東化学株式会社(KANTO)
|
12171-3A |
ｐ‐ヒドロキシフェニル酢酸
p‐Hydroxyphenylacetic acid |
156-38-7 |
100g |
￥17710 |
2024-07-01 |
購入 |
4-ヒドロキシフェニル酢酸 化学特性,用途語,生産方法
外観
白色〜わずかにうすい褐色, 結晶〜結晶性粉末
溶解性
エタノール, トルエンに易溶, 水に可溶。エタノール及びトルエンに溶けやすく、水にやや溶けやすい。
用途
有機合成原料。酵素、糖及びホルモンの定量。
使用上の注意
不活性ガス封入
化学的特性
4-Hydroxyphenylacetic acid is a white to cream or light tan crystalline powder. sublimation. Insoluble in cold water, soluble in hot water, ether, ethanol, ethyl acetate. In the case of ferric chloride, it is a purple-green precipitate. It is used as a pharmaceutical raw material for the synthesis of cephalosporin antibiotics, antipyretic analgesics.
使用
A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development.
定義
ChEBI: 4-hydroxyphenylacetic acid is a monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group. It has a role as a plant metabolite, a fungal metabolite, a human metabolite and a mouse metabolite. It is a monocarboxylic acid and a member of phenols. It derives from an acetic acid. It is a conjugate acid of a 4-hydroxyphenylacetate.
製造方法
4-Hydroxyphenylacetic acid is synthesized by diazotization and hydrolysis of 4-aminophenylacetic acid.
4-aminophenylacetic acid and alkali solution are prepared into sodium salt, and then sulfuric acid is added. Cool to 0°C, control the temperature at 0-5°C, and add sodium nitrate solution dropwise, and the reaction is completed for 0.5h. The obtained diazonium was added dropwise to dilute sulfuric acid at 90-95°C for about 1 hour, and the reaction was continued for 1 hour. The reaction solution was decolorized and filtered, cooled and extracted with ethyl acetate, and the extract was recovered with ethyl acetate to obtain 4-Hydroxyphenylacetic acid. The yield is about 85%.
生物活性
4-Hydroxyphenylacetic acid (4-HPA) is an important microbial-derived metabolite of polyphenols in the intestinal tract
[4].
純化方法
Crystallise the acid from water or Et2O/pet ether. The p-bromophenacyl ester has m 117o (from EtOH). [Beilstein 10 II 112, 10 III 430, 10 IV 543.]
4-ヒドロキシフェニル酢酸 上流と下流の製品情報
原材料
準備製品
4-ヒドロキシフェニル酢酸 生産企業
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4-ヒドロキシフェニル酢酸 スペクトルデータ(1HNMR、IR1、IR2、MS、Raman)
156-38-7(4-ヒドロキシフェニル酢酸)キーワード:
- 156-38-7
- (p-hydroxyphenyl)-aceticaci
- 4-Hydroxybenzeneacetic acid
- 4-Hydroxyphenylacetic acid Vetec(TM) reagent grade, 98%
- Arbidol Impurity F HCl
- Levothyroxine Sodium Impurity d
- NSC 27460
- Acetic acid, (p-hydroxyphenyl)-
- ethanoicacid,4-hydroxyphenyl-
- Parahydroxy phenylacetic acid
- RARECHEM AL BO 0188
- P-HYDROPHENYLACETIC ACID
- AKOS 236-100
- 4-HYDROXYPHENYLACETIC ACID
- 4-HYDROXYPHENYLACETIC ACID, FOR FLUORESC ENCE
- 4-HydroxyphenylacetidAcid
- Atenolol Impurity (4-Hydroxyphenylacetic
- Atenolol Impurity K
- 4-hydrophenylacetic acid
- 4-Hydroxyphenylacetic acid,98%
- HYDROXYPHENYLACETIC ACID, 4-(RG)
- 4-Hydroxyphenylacetic acid, 98% 100GR
- Atenolol iMpurity F(4-Hydroxyphenylacetic acid)
- 4-hydroxy-benzeneaceticaci
- 4-hydroxybenzeneaceticacid
- 4-hydroxyphenylethanoicacid
- Hydroxyphenylacetic aci
- 4-Hdroxyphenylacetic acid
- The hydroxy benzene acetic acid
- 4-Hydroxyphenylacetic acid 98%
- p-Hydroxybenzeneacetic acid
- 4-ヒドロキシフェニル酢酸
- 2-(4-ヒドロキシフェニル)酢酸
- p-ヒドロキシベンゼン酢酸
- p-ヒドロキシフェニル酢酸
- 4-ヒドロキシベンゼン酢酸
- (4-ヒドロキシフェニル)酢酸
- ヒドロキシフェニル酢酸
- (p-ヒドロキシフェニル)酢酸
- P‐ヒドロキシフェニル酢酸
- 4-ヒドロキシフェニル酢酸, 99%
- 代謝産物