三ケイ酸マグネシウム 化学特性,用途語,生産方法
外観
白色～ほとんど白色, 粉末
定義
本品は、次の化学式で表される無機化合物である。
溶解性
水、エタノール及びアセトンにほとんど溶けない。
解説
三ケイ酸マグネシウム, 以下の4種類が知られている．【Ⅰ】オルトケイ酸マグネシウム：Mg2SiO4(140.67)．IUPAC体系(付加命名法)(テトラオキシドケイ酸(4－))マグネシウム．天然には苦土かんらん石(forsterite)として存在する．人工的には，SiO2とMgOを加熱溶融反応させると得られる．無色の斜方晶系結晶．独立した正四面体型のSiO4からなる．密度3.2 g cm－3．融点1910 ℃．水に不溶．アルカリ水溶液には徐々に溶ける．HCl，HNO3などでは加水分解する．耐火物材料，高炉スラグの融剤として使用される．[CAS 10034-94-3]【Ⅱ】メタケイ酸マグネシウム：(Mg3SiO3)n(100.39×n)．天然には輝石類の頑火輝石(enstatite)(斜方晶系)，斜頑火輝石(clinoenstatite)(単斜晶系)がある．人工的には，SiO2とMgOを混合，溶融して反応させてつくる．四面体型のSiO4が，Oを共有して鎖状に並んだ構造をもつ．密度3.19 g cm－3．1560 ℃ で分解する．水や希酸に不溶．アルカリ水溶液には徐々に溶ける．[CAS 13776-74-4]【Ⅲ】二ケイ酸三マグネシウム：Mg3Si2O5(OH)4(277.11)．天然には，蛇紋石(serpentine)として産出する．単斜晶系．繊維状の温石綿(chrysotile)(石綿の一種)，板状のアンチゴライト(antigorite)などの多形を示す．石綿として化学物質排出把握管理促進法・特定第1種指定化学物質(ヒトへの発がん性を有する物質)．労働安全衛生法-製造が禁止されている物質．[CAS 12001-29-5]【Ⅳ】三ケイ酸二マグネシウム：Mg2Si3O8(260.86)．天然には，海泡石(sepiolite)として産出する．人工的には，Na2SiO3とMgSO4を原料として，多孔質の粉末が得られる．胃の制酸剤や，クロマトグラフィーなどに用いられる．[CAS 14987-04-3]
森北出版「化学辞典（第2版）
化粧品の成分用途
不透明化剤、滑沢剤、抗ケーキング剤、親水性増粘剤、吸着剤、研磨.スクラブ剤、増量剤
化学的特性
The USP 32 describes magnesium trisilicate as a compound of
magnesium oxide and silicon dioxide with varying proportions of
water. It contains not less than 20.0% of magnesium oxide and not
less than 45.0% of silicon dioxide. The PhEur 6.0 similarly
describes magnesium trisilicate as having a variable composition
corresponding to the approximate formula Mg
2Si
3O
8·xH
2O. It
contains not less than 29.0% of magnesium oxide and not less than
the equivalent of 65.0% of silicon dioxide, both calculated with
reference to the ignited substance.
Magnesium trisilicate occurs as an odorless and tasteless, fine,
white-colored powder that is free from grittiness.
使用
Industrial odor absorbent, decolorizing agent,
antioxidant, medicine (antacid).
定義
USP specifies not less
than 20% magnesium oxide and 45% SiO2, similar
to the FCC requirements for magnesium silicate.
See talc.
調製方法
Magnesium trisilicate may be prepared from sodium silicate and
magnesium sulfate. It also occurs in nature as the minerals
meerschaum, parasepiolite, and sepiolite.
応用例（製薬）
Magnesium trisilicate is used in oral pharmaceutical formulations
and food products as a glidant. It is also used therapeutically as an
antacid, and also for the treatment of ciprofloxacin overdose or
toxicity.
安全性
Magnesium trisilicate is used in oral pharmaceutical formulations
and is generally regarded as an essentially nontoxic and nonirritant
material.
When administered orally, magnesium trisilicate is neutralized in
the stomach to form magnesium chloride and silicon dioxide; some
magnesium may be absorbed. Caution should be used when
concentrations greater than 50 mEq of magnesium are given daily
to persons with impaired renal function, owing to the risk of
hypermagnesemia.
Therapeutically, up to about 2 g of magnesium trisilicate may be
taken daily as an antacid.
Reported adverse effects include the potential for osmotic
diarrhea in the elderly using antacids containing magnesium
trisilicate;and the potential for the formation of bladder and
renal calculi following the long-term use of magnesium trisilicate as
an antacid.
貯蔵
Magnesium trisilicate is stable if stored in a well-closed container in
a cool, dry place.
不和合性
Magnesium trisilicate, when taken with drugs such as mebeverine
hydrochloride,proguanil,norfloxacin,sucralfate, and tetracycline,
may cause a reduction in bioavailability via binding or
chelation. The dissolution rate of folic acid, erythromycin
stearate,paracetamol, and chloroquine phosphate may be
retarded by adsorption onto magnesium trisilicate. Antimicrobial
preservatives, such as the parabens, may be inactivated by the
addition of magnesium trisilicate.
Magnesium trisilicate is also readily decomposed by mineral
acids.
規制状況(Regulatory Status)
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (oral tablets).
Included in nonparenteral medicines licensed in the UK. Included in
the Canadian List of Acceptable Non-medicinal Ingredients.
三ケイ酸マグネシウム 上流と下流の製品情報
原材料
準備製品