L-(+)-酒石酸 化学特性,用途語,生産方法
外観
白色の結晶
定義
本品は、次の化学式で表される有機酸である。
溶解性
水に易溶 (115.04g/100g水, 0℃)。アセトン, エタノールに可溶。エーテルに難溶。水に極めて溶けやすく、エタノールに溶けやすく、ジエチルエーテルにほとんど溶けない。
無機性値/有機性値
500/80
用途
酸性調味料、写真工業
化粧品の成分用途
pH調整剤、香料
効能
緩衝剤, 矯味・矯臭剤
商品名
酒石酸 (健栄製薬); 酒石酸 (小堺製薬); 酒石酸 (小堺製薬); 酒石酸 (山善製薬); 酒石酸 (日興製薬)
化学的特性
Tartaric acid occurs as colorless monoclinic crystals, or a white or almost white crystalline powder. It is odorless, with an extremely tart taste. L-(+)-Tartaric Acid is a naturally occurring chemical compound found in berries, grapes and various wines. It provides antioxidant properties and contributes to the sour taste within these products.
使用
L(+)-Tartaric acid is widely utilized in pharmaceutical industries. It is used in soft drinks, confectionaries, food products, gelatin desserts and as a buffering agent. It forms a compound, TiCl2(O-i-Pr)2 with Diels-Alder catalyst and acta as a chelate agent in metal industries. Owing to its efficient chelating property towards metal ions, it is used in farming and metal industries for complexing micronutrients and for cleaning metal surfaces, respectively.
調製方法
Tartaric acid occurs naturally in many fruits as the free acid or in
combination with calcium, magnesium, and potassium.
Commercially, L-(＋)-tartaric acid is manufactured from potassium
tartrate (cream of tartar), a by-product of wine making.
Potassium tartrate is treated with hydrochloric acid, followed by the
addition of a calcium salt to produce insoluble calcium tartrate.
This precipitate is then removed by filtration and reacted with 70%
sulfuric acid to yield tartaric acid and calcium sulfate.
定義
ChEBI: L-tartaric acid is a tetraric acid that is butanedioic acid substituted by hydroxy groups at positions 2 and 3. It is a conjugate acid of a L-tartrate(1-). It is an enantiomer of a D-tartaric acid.
一般的な説明
L(+)-Tartaric acid belongs to the group of carboxylic acids, and is abundantly found in grapes and wine. It is widely used in drugs, food, and beverage industry.
応用例（製薬）
Tartaric acid is used in beverages, confectionery, food products, and
pharmaceutical formulations as an acidulant. It may also be used as
a sequestering agent and as an antioxidant synergist. In pharmaceutical
formulations, it is widely used in combination with
bicarbonates, as the acid component of effervescent granules,
powders, and tablets.
Tartaric acid is also used to form molecular compounds (salts
and cocrystals) with active pharmaceutical ingredients to improve
physicochemical properties such as dissolution rate and solubility.
安全性プロファイル
Moderately toxic by intravenous route. Mildly toxic by ingestion. Reaction with silver produces the unstable silver tartrate. When heated to decomposition it emits acrid smoke and irritating fumes.
安全性
L(+)-Tartaric acid is widely used in food products and oral, topical, and parenteral pharmaceutical formulations. It is generally regarded as a nontoxic and nonirritant material; however, strong tartaric acid solutions are mildly irritant and if ingested undiluted may cause gastroenteritis.
An acceptable daily intake for L-(＋)-tartaric acid has not been set by the WHO, although an acceptable daily intake of up to 30 mg/kg body-weight for monosodium L-(＋)-tartrate has been established. LD50 (mouse, IV): 0.49 g/kg.
貯蔵
The bulk material is stable and should be stored in a well-closed
container in a cool, dry place.
不和合性
Tartaric acid is incompatible with silver and reacts with metal
carbonates and bicarbonates (a property exploited in effervescent
preparations).
規制状況(Regulatory Status)
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (IM and IV
injections; oral solutions, syrups and tablets; sublingual tablets;
topical films; rectal and vaginal preparations). Included in
nonparenteral medicines licensed in the UK. Included in the
Canadian List of Acceptable Non-medicinal Ingredients.
L-(+)-酒石酸 上流と下流の製品情報
原材料
準備製品
(1R,2R)-(-)-1,2-シクロヘキサンジアミン
(1S,2S)-(-)-1,2-ジフェニルエチレンジアミン
(2S,3S)-(+)-1,4-ビス(ジフェニルホスフィノ)-2,3-O-イソプロピリデン-2,3-ブタンジオール
2-メチル-1H-ピロロ[2,3-b]ピリジン
(-)-(1S,4R)-4-Aminocyclopent-2-enecarboxylic acid
(3R,1α,4α)-1-アザビシクロ[2.2.2]オクタン-3α-オール
酒石酸ジアンモニウム
trans-2,5-ジメチルピペラジン
D-(-)-酒石酸
2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol
(+)-N-ベンジル-(3R,4R)-ビス(ジフェニルホスフィノ)ピロリジン
レボスルピリド
(+)-4,5-ビス[ヒドロキシ(ジフェニル)メチル]-2,2-ジメチル-1,3-ジオキソラン
(1S,2S)-(+)-1,2-シクロヘキサンジアミン
(S)-(-)-1-フェニルエチルアミン
1H-ピロロ[3,2-c]ピリジン
メタラミノール
[1R,4R,(+)]-1,7,7-トリメチルビシクロ[2.2.1]ヘプタン-2β-アミン
レバミゾール塩酸塩
トリス(2-メチルフェニル)ホスフィン
1H-Azepine-4-carboxylicacid,hexahydro-,methylester,(4R)-(9CI)
(1R,2R)-(+)-1,2-シクロヘキサンジアミンL-酒石酸
(3S)-3-(ヒドロキシメチル)ピペリジン-1-カルボン酸TERT-ブチル
(R)-(-)-3-キヌクリジノール塩酸塩