プロピルアミン 化学特性,用途語,生産方法
外観
無色澄明の液体
溶解性
水, アルコール, エーテルと混和。水、エタノール及びジエチルエーテルに極めて溶けやすい。
解説
プロピルアミン，化学式 CH3(CH2)2NH2 。ハロゲン化プロピルに，アルコール性アンモニアを作用させてつくった塩基性液体。アンモニア臭がある。沸点 49℃。
ブリタニカ国際大百科事典 小項目事典 ブリタニカ
用途
ゴム工業?染料?繊維の仕上げ剤、腐食防止剤。
応用
ポリアクリレートの応用範囲は広くその機能は使用される分野によって大きく異なりますたとえば医療分野ではポリアクリレートは創傷被覆材やコンタクトレンズに使われていますまた農業では水保持材としての用途で土壌の効率的な水分管理に貢献していますさらに日常生活では非常に吸収性が高いことからベビーおむつやペットシートの吸収体としても使用されています
化学的特性
プロピルアミンは化学式がCH3CH2CH2NH2で表される有機化合物ですこの化合物はアミン類に分類され特有の強い臭気を持っていますアミンはアンモニアから水素原子の一部がアルキルやアリール基に置換されたものでプロピルアミンはその中でも最も単純な構造を持つ一例です
化学的特性
n-Propylamine, also known as propylamine, is a colorless liquid with a pungent odor resembling ammonia. It has strong basic properties, leading to its easy formation of salts when combined with acids. Its reactivity is similar to that described for the other short chain aliphatic amines (Astel 1961).
使用
n-Propylamine is used as an intermediate inmany organic reactions. It has been used in the synthesis of single crystals of siliceous ferrierite.
調製方法
There are several methods employed in the manufacture of propylamine. Typically,
ammonia and propanol are reacted over a dehydration catalyst at high temperature
and pressure. Ammonia, propanol, and hydrogen can also be reacted over a
dehydrogenation catalyst such as metallic silver. Propylamine can also be synthesized
from propionaldehyde and ammonia with a Raney nickel catalyst (Schweizer
et al 1978).
安全性
プロピルアミンは強い刺激臭があり人体に対しても刺激を与えることが知られています皮膚や目呼吸器に対して刺激を及ぼす可能性があるため取り扱いには十分な注意が必要ですまた環境への放出も避けるべきであり取り扱い後の廃棄物は適切に処理する必要があります
一般的な説明
A clear colorless liquid with an ammonia-like odor. Flash point -35°F. Less dense than water and soluble in water. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Used in chemical analysis and to make other chemicals.
空気と水の反応
Highly flammable. Slightly soluble in water.
反応プロフィール
Colorless, alkaline liquid, very volatile (b. p. 48° C), moderately toxic, highly flammable. Dangerous fire hazard when exposed to heat, flame, sparks, or strong oxidizers. When heated to decomposition Propylamine emits toxic fumes of oxides of nitrogen. Incompatible with triethylaluminum, complex may explode on sublimation [Chini, P. et al., Chim. e Ind (Milan), 1962, 44, p. 1220].
危険性
Highly flammable, dangerous fire risk,
explosive limits in air 2–10%, use alcohol foam
to extinguish. Strong irritant to skin and tissue.
健康ハザード
n-Propylamine is a strong irritant and a mod erately toxic substance. the toxic routes areinhalation, ingestion, and absorption throughthe skin. Contact of the liquid on the skincan cause burns and possibly skin sensitization. Irritation in the eyes from exposure tohigh concentrations can be severe. It is a respiratory tract irritant, similar to ethylamine.Inhalation of 2300 ppm of n-propylamine for4 hours caused labored breathing, hepatitis,and hepatocellular necrosis in rats. It is somewhat less toxic than ethylamine by oral anddermal routes.
LC50 value, inhalation (mice): 2500 mg/m
3/2 hr
LD50 value, oral (rats): 570 mg/kg
LD50 value, skin (rabbits): 560 mg/kg.
火災危険
Highly flammable liquid; flash point (closed
cup) -37°C (-35°F); vapor density 2.0
(air = 1), vapor can travel a considerable distance to a source of ignition and flash back;
autoignition temperature 318°C (604°F); fire extinguishing agent: dry chemical, CO2, or
“alcohol” foam; water should be used to keep
fire-exposed containers cool and to flush and
dilute the spill.
n-Propylamine forms explosive mixtures
in air; LEL and UEL values are 2.0% and
10.4% by volume in air, respectively. There
is no report of explosion associated with this
compound. It is expected to exhibit violent
reactions characteristic of lower aliphatic
primary amines .
生産方法
プロピルアミンは主に工業的な方法で製造されますその一つの方法はプロパンとアンモニアを高温高圧下で反応させるというものですこのプロセスは触媒を用いることが一般的で高い収率を出すことが可能です
化学性质
ポリアクリレートにはいくつかの異なる形が存在します主なものとしてはポリメタクリル酸メチルPMMAポリアクリル酸ナトリウムPAASなどがありますPMMAは「アクリルガラス」としても知られておりその透明性と耐候性から建材や車の窓などに使われます一方でPAASは特にその吸水性能が高く評価されており土壌の水分保持材やおむつの吸収材に利用されています
工業用途
Propylamine is important as a chemical intermediate for rubber chemicals, dyestuffs,
propyl isocyanate, textile and leather finishing resins and corrosion inhibitors.
It is also used in the production of pharmaceuticals such as Prilocaine,
pesticides including Profluralin and in petroleum additives. In 1976, 500 tons of
propylamine were manufactured in the U.S. (HSDB 1988).
安全性プロファイル
Moderately toxic by
inhalation, ingestion, and skin contact
routes. A skin and severe eye irritant.
Possibly a skin sensitizer. Very dangerous
fire hazard when exposed to heat, flame, or
oxidizers. Explosive in the form of vapor
when exposed to heat or flame. To fight
fire, use alcohol foam. When heated to
decomposition it emits toxic fumes of NOx.
Incompatible with triethynyl aluminum. See
also AMINES.
職業ばく露
Propylamine is used to make textile
resins, drugs, pesticides, and other chemicals.
概要
プロピルアミンはそのシンプルな構造にもかかわらず多様な工業用途を持つ化学物質ですその製造や用途は広範囲にわたりますがその取り扱いには慎重を要します化学業界だけでなく環境科学の観点からもその影響と安全性に対する理解が求められています
代謝
To date, there are several studies which indicate that propylamine may be
metabolized in many animal species, including man. When propylamine hydrochloride
was administered to humans orally, little of the parent compound was
recovered in the urine (Rechenberger 1940). It has also been reported that dogs are
capable of metabolizing propylamine (Bernhard 1938). McEwen et al (1966)
demonstrated that monoamine oxidase, purified from rabbit serum, was capable of
oxidizing propylamine, although less actively than substituted phenylethylamines
such as dopamine. Further characterization revealed that the protonated amine is
bound by an unprotonated enzyme group, that the enzyme active site is composed
of hydrophobic residues, and that interaction of the amine residues determines
maximal velocity and affinity constant (McEwen and Sober 1967). Oxidation of
the amine could be stimulated by the presence of aliphatic alcohols which
apparently bond in a tertiary complex with the enzyme and substrate, thereby
increasing the effectiveness of substrate binding.
Other investigators have provided evidence that propylamine may not be a
substrate for tissue monoamine oxidase. When given intraperitoneally to rats it had
no effect on the liver enzyme and little effect on activity in the brain (Valiev 1974).
Early work by Pugh and Quastel (1937) indicated that slices of rat brain did not
metabolize propylamine.
輸送方法
UN1277 Propylamine, Hazard Class: 3; Labels:
3-Flammable liquid, 8-Corrosive material.
純化方法
Distil the amine from zinc dust, under reduced pressure, in an atmosphere of nitrogen. [Beilstein 4 IV 464.]
不和合性
Propylamine Vapors may form explosive mixture with air. Violent reaction on contact with oxidizers and mercury, strong acids; organic anhydrides; isocyanates, aldehydes, nitroparrafins, halogenated hydrocarbons; alcohols and many other compounds. Attacks many metals and alloys, especially those of copper. Aqueous solution is acidic and may attack glass.
廃棄物の処理
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations
governing storage, transportation, treatment, and waste
disposal.
プロピルアミン 上流と下流の製品情報
原材料
準備製品