ゲルダナマイシン

ゲルダナマイシン 価格 もっと(25)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01LKTG1646	ゲルダナマイシン Geldanamycin	30562-34-6	100μg	￥7900	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01MAS089452	ゲルダナマイシン Geldanamycin	30562-34-6	100mg	￥1087000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01COBQA-1306	Geldanamycin	30562-34-6	250mg	￥195000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01LKTG1646	Geldanamycin	30562-34-6	100ug×5	￥26700	2023-06-01	購入
東京化成工業	G0334	ゲルダナマイシン >98.0%(HPLC) Geldanamycin >98.0%(HPLC)	30562-34-6	10mg	￥30400	2024-03-01	購入

ゲルダナマイシン 化学特性,用途語,生産方法

外観

結晶～粉末

溶解性

メタノールに溶ける。

用途

抗腫瘍性抗生物質です。ベ ンゾキノイド 骨 格 を 有 し、HSP90（Heat Shock Protein 90）の ATP 結合部位に結合 することで HSP90 の機能阻害作用を示しま す。

用途

薬理研究用。

説明

Geldanamycin from Streptomyces hygroscopicus.
Geldanamycin is a benzoquinone ansamycin antitumor antibiotic. Geldanamycin binds specifically to Hsp90 (Heat Shock Protein 90) and to its endoplasmic reticulum homologue GP96. The Hsp90 chaperone is required for the activation of several families of eukaryotic protein kinases and nuclear hormone receptors, many of which are proto-oncogenic and play a prominent role in cancer. The geldanamycin antibiotic has antiproliferative and antitumor effects, as it binds to Hsp90, inhibits the Hsp90-mediated conformational maturation/refolding reaction, and results in the degradation of Hsp90 substrates. Hsp90 also plays a key role in regulating the physiology of cells exposed to environmental stress and thus, geldanamycin interferes with cellular stress response.
Geldanamycin was found to be a potent antibiotic active at nanomolar concentrations against 60 cell lines as well as in mouse tumor models.
It is an inhibitor of proto-oncogenic protein kinases, such as erbB22, EFG receptor tyrosine kinases, and non-receptor tyrosine kinases, such as v-src and Raf-1. In addition, it is a potent inhibitor of the nuclear hormone receptor family including the estrogen and androgen hormone receptors.

化学的特性

Yellow to Orange Powder

使用

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

定義

ChEBI: An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.

一般的な説明

Chemical structure: benzenoid

生物活性

Selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (K d = 1.2 μ M) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors.

ゲルダナマイシン 上流と下流の製品情報

原材料

準備製品

ゲルダナマイシン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12788	58
Hebei Yanxi Chemical Co., Ltd.	+8617531153977	allison@yan-xi.com	China	5854	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18134	58
Shaanxi Xianhe Biotech Co., Ltd	+8617709210191	Jerry@xhobio.com	China	885	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21628	55
Hubei XinRunde Chemical Co., Ltd.	+8615102730682	bruce@xrdchem.cn	CHINA	566	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29856	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	+8613815430202	sale02@cqherb.com	CHINA	376	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Hebei shuoxi biotechnology co. LTD	+8613081092107		CHINA	964	58

30562-34-6(ゲルダナマイシン)キーワード:

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• 30562-34-6
• Geldanamycin from Streptomyces hygroscopicus, ≥98% (HPLC)
• geldanamycin 30562-34-6
• GELDANAMYCIN;NSC-122750; NSC 122750; NSC122750
• Geldanamycin (NSC122750)
• CS-503
• Geldanamycin, Streptomyces hygroscopicus - CAS 30562-34-6 - Calbiochem
• [(4Z,6E,8R,9R,10Z,12R,13R,14R,16R)-13-Hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaen-9-yl] carbamate
• (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21(1)-pentene-3,20,22-trione
• CP-122634
• 9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione 9-Carbamate
• NSC 212518
• GELDANAMYCIN FROM STRE
• GeldanaMycin, froM StreptoMyces hygroscopicus var geldanus
• GeldanaMycin froM StreptoMyces hygroscopi
• 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate
• Geldanamycin [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
• GeldanamyCln
• Geldanamycin, 99%, from Streptomyces hygroscopicus var geldanus, a HSP90 inhibitor
• nsc122750
• GELDANAMYCIN
• GELDANAMYCIN, STREPTOMYCES HYGROSCOPICUS
• GA
• 9,13-DIHYDROXY-8,14,19-TRIMETHOXY-4,10,12,16-TETRAMETHYL-2-AZABICYCLO[16.3.1]DOCOSA-4,6,10,18,21-PENTAENE-3,20,22-TRIONE, 9-CARBAMATE
• GELDANAMYCIN (GDM)
• GELDANAMYCIN FROM STREPTOMYCES*HYGROSCOP ICUS
• GELDANAMYCIN, 99+%
• Streptomyces hygroscopicus
• 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate (8CI)
• [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
• [(8Z,12Z,14Z)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
• ゲルダナマイシン
• (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-9-[(アミノカルボニル)オキシ]-13-ヒドロキシ-8,14,19-トリメトキシ-4,10,12,16-テトラメチル-2-アザビシクロ[16.3.1]ドコサ-4,6,10,18,21(1)-ペンタエン-3,20,22-トリオン
• ゲルダナマイシン, STREPTOMYCES HYGROSCOPICUS
• ゲルダナマイシン, ストレプトミセス属由来
• ゲルダナマイシン STREPTOMYCES HYGROSCOPICUS由来
• (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-ヒドロキシ-8,14,19-トリメトキシ-4,10,12,16-テトラメチル-3,20,22-トリオキソ-2-アザビシクロ[16.3.1]ドコサ-1(21),4,6,10,18-ペンタエン-9-イル カルバマート
• 抗腫瘍抗生物質