N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite
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- CAS番号.
- 142808-44-4
- 化学名:
- 别名:
- 英語名:
- N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite
- 英語别名:
- Gemcitabine 3'-CE Phosphoramidite;N4-Bz-DMT-2',2'-difluoro-dC-CE-Phosphoramidite;DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite;DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite;DMTr-2’,2’-di fluoro-dC(Bz)-3’-CED-phosphoramidite;5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite;N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite;N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',2'-difluoro-2'-deoxycytidine;N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite;5'-O-DMT-N4-Benzoyl-2',2'-difluoro-2'-deoxycytidine 3'-CE phosphoramidite
- CBNumber:
- CB84659422
- 化学式:
- C46H50F2N5O8P
- 分子量:
- 869.89
- MOL File:
- 142808-44-4.mol
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N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite 物理性質
- 酸解離定数(Pka):
- 8.38±0.20(Predicted)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite 価格
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N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite 化学特性,用途語,生産方法
使用
N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
合成
1.Dissolve 5'-Dimethoxytrityl-N 4-benzoyl-2',2'-difluoro-2'-deoxycytidine (1 equiv., 0.4 mmol, 270 mg)in anhydrous acetonitrile (6 ml).
2.Add 0.5 M solution of ethylothiotetrazole (1.6 equiv., 0.65 mM, 1.3 ml) in anhydrous acetonitrile and 2-cyanoethyl-bis-(N,N'-diisopropropyl)phosphoramidite (1.43 equiv., 0.57 mmol, 0.2 ml) to the above solution.
3.Stir the reaction mixture at room temperature for 1 h to obtain product.
N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite 上流と下流の製品情報
原材料
準備製品
N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite 生産企業
Global( 35)Suppliers
- 142808-44-4
- N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite
- N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',2'-difluoro-2'-deoxycytidine
- 5'-O-DMT-N4-Benzoyl-2',2'-difluoro-2'-deoxycytidine 3'-CE phosphoramidite
- N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite
- Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2',2'-difluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
- DMTr-2’,2’-di fluoro-dC(Bz)-3’-CED-phosphoramidite
- N4-Benzoyl-5’-O-(4,4’-dimethoxy trityl) -2’,2’-difluoro-2’-deoxycytidine 3’-O-[(2-cyanoethyl) (N,N-diisopropyl)]-phosphoramidite
- N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',2'-difluoro-2'-deoxycytidine-3'-cyanoethyl Phosphoramidite
- N4-Bz-DMT-2',2'-difluoro-dC-CE-Phosphoramidite
- 5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite
- (2R,3R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4,4-difluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- Gemcitabine 3'-CE Phosphoramidite
- DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite
- N4-Benzoyl-2'-deoxy-5'-O-DMTr-2', 2'-difluorocytidine 3'-cyanoethyl phosphoramidite
- N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',2'-difluoro-2'-deoxycytidine-3'-cyanoethylPhosphoramidite
- DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite
- (2R,3R,5R)-5-[4-Benzamido-2-oxopyrimidin-1(2H)-yl]-2-[[bis(4-methoxyphenyl)(phenyl)methoxy]methyl]-4,4-difluorotetrahydro-3-furyl (2-Cyanoethyl) Diisopropylphosphoramidite