NS8593 塩酸塩

NS8593 塩酸塩 価格 もっと(4)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TOC4597	NS 8593 hydrochloride	875755-24-1	10mg	￥74000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TOC4597	NS 8593 hydrochloride	875755-24-1	50mg	￥303000	2024-03-01	購入
Sigma-Aldrich Japan	N2538	NS8593 塩酸塩 ≥98% (HPLC), powder NS8593 hydrochloride ≥98% (HPLC), powder	875755-24-1	5mg	￥31360	2021-03-23	購入
Sigma-Aldrich Japan	N2538	NS8593 塩酸塩 ≥98% (HPLC), powder NS8593 hydrochloride ≥98% (HPLC), powder	875755-24-1	25mg	￥113600	2021-03-23	購入

NS8593 塩酸塩 化学特性,用途語,生産方法

説明

NS 8593 is an inhibitory gating modifier of small-conductance calcium-activated potassium (K_Ca2/SK) channels (K_ds = 0.42, 0.6, and 0.73 μM for K_Ca2.1/SK1, K_Ca2.2/SK2, and K_Ca2.3/SK3, respectively, in the presence of calcium) that decreases the calcium sensitivity of SK channels. It is selective for K_Ca2/SK channels over intermediate- (K_Ca3.1/IK_Ca1) and large-conductance (BK) potassium channels at 10 μM. NS 8593 induces relaxation of potassium- or acetylcholine chloride-precontracted isolated tracheal rings from wild-type mice (IC₅₀s = 8.9 and 39.8 μM, respectively) or from mice in an ovalbumin-induced model of allergic asthma (IC₅₀s = 16.4 and 32.2 μM, respectively). It inhibits aerosolized acetylcholine chloride-induced increases in respiratory system resistance in mice when administered as an aerosol at a dose of 500 μM. NS 8593 (5 mg/kg) decreases the duration of burst-pacing-induced atrial fibrillation in normotensive and spontaneously hypertensive rats.

使用

NS8593 hydrochloride has been used to study its effect on the growth of MDA-MB-231 cells (M.D. Anderson and metastasis breast cancer cells).

Biochem/physiol Actions

The compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reversibly inhibited recombinant SK3-mediated currents (human and rat SK3) with potencies around 100 nM. NS8593 did not inhibit 125I-apamin binding. NS8593 decreased the calcium sensitivity by shifting the activation curve for Ca2+ to the right, only slightly affecting the maximal Ca2+-activated SK current. NS8593 inhibited all the SK1-3 subtypes Ca2+-dependently (Kd = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+. NS8593 did not affect the calcium-activated potassium channels of intermediate and large conductance (hIK and hBK channels, respectively). NS8593-mediated inhibition was prevented in the presence of a high concentration of the positive modulator NS309.

NS8593 塩酸塩 上流と下流の製品情報

原材料

準備製品

NS8593 塩酸塩 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32376	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38838	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Shanghai Rechem science Co., Ltd.	021-31433387 15618786686	sales@rechemscience.com	China	2976	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4648	55
Shanghai YuanYe Biotechnology Co., Ltd.	021-61312847; 18021002903	3008007409@qq.com	China	71826	60
Shanghai SuperLan Chemcial Technique Centre	021-2022843681 15618226720	lucy@atkchemical.com	China	10014	58

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• 875755-24-1
• NS8593 HYDROCHLORIDE
• : N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-1H-Benzimidazol-2-amine hydrochloride
• NS8593
• N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-benzimidazol-2-amine
• NS8593 HCl
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• NS8593 hydrochloride, 10 mM in DMSO
• NS8593 塩酸塩