N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE
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N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE 속성
- 끓는 점
- 78-80 °C100 mm Hg(lit.)
- 밀도
- 0.83 g/mL at 25 °C(lit.)
- 굴절률
- n
20/D 1.411(lit.)
- 인화점
- 84 °F
- 저장 조건
- 2-8°C
- 용해도
- THF, 에테르, 펜탄, CH2Cl2에 용해됩니다.
- 산도 계수 (pKa)
- 5.94±0.70(Predicted)
- 물리적 상태
- 투명한 액체
- 색상
- 무색 내지 거의 무색
- Specific Gravity
- 0.83
- Hydrolytic Sensitivity
- 7: reacts slowly with moisture/water
- BRN
- 1920452
- InChI
- 1S/C6H19NOSi2/c1-9(2,3)7-8-10(4,5)6/h7H,1-6H3
- InChIKey
- ZAEUMMRLGAMWKE-UHFFFAOYSA-N
- SMILES
- C[Si](C)(C)NO[Si](C)(C)C
- CAS 데이터베이스
- 22737-37-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi,C | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 10-36/37/38-34 | ||
| 안전지침서 | 26-36-45-36/37/39 | ||
| 유엔번호(UN No.) | UN 1993 3/PG 3 | ||
| WGK 독일 | 3 | ||
| F 고인화성물질 | 10-21 | ||
| TSCA | No | ||
| 위험 등급 | 3.2 | ||
| 포장분류 | III | ||
| HS 번호 | 29319019 | ||
| 스토리지 클래스 | 3 - Flammable liquids | ||
| Hazard Classifications | Eye Dam. 1 Flam. Liq. 3 Skin Corr. 1B |
N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE C화학적 특성, 용도, 생산
화학적 성질
Clear colorless liquid물리적 성질
bp 137–139°C, 78–80°C/100 mmHg; d 0.830 g cm3; flash point 28°C.용도
N,O-Bis(trimethylsilyl)hydroxylamine is a protected, lipophilic form of hydroxylamine. It reacts with a variety of electrophiles predominantly by attack on the nitrogen nucleophilic center. Reaction with acid chlorides (1 equiv) in the presence of triethylamine gives N,O-bis(trimethylsilyl)- hydroxamic acids by N-acylation.A related reagent, tris(trimethylsilyl) hydroxylamine, gives the same product in high yields, also by N-acylation.Hydrolysis gives the free hydroxamic acids, whereas thermal fragmentation affords isocyanates (eq 1).
제조 방법
N,O-Bis(trimethylsilyl)hydroxylamine can be prepared in 69% yield by treating dry hydroxylamine with equiv chlorotrimethylsilane and equiv triethylamine.A safer preparation, which avoids the use of the explosive solid, hydroxylamine, uses the reaction of hydroxylamine hydrochloride with excess hexamethyldisilazane (71–75% yield).Alternatively, neutralization of hydroxylamine hydrochloride with ethylenediamine followed by addition of chlorotrimethylsilane can be used.일반 설명
N,O-Bis(trimethylsilyl)hydroxylamine on reaction with 9-chloro-9-borafluorene yields 10-trimethylsilyloxy-9-aza-10-boraphenanthrene. It reacts with free phenolic steroids during the analysis of conjugated estrogen tablets and injectable formulations by GLC.N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE 준비 용품 및 원자재
원자재
준비 용품
N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE 공급 업체
글로벌( 101)공급 업체
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| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 |
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| career henan chemical co | +86-0371-86658258 +8613203830695 |
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| Alfa Chemistry | |
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| Aston Chemical | 13000000000 |
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| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 |
info@dycnchem.com | China | 52705 | 58 |
| Alfa Chemistry | +1-5166625404; |
Info@alfa-chemistry.com | United States | 20405 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; |
peter68@ptchemgroup.com | China | 35425 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 |
trendseenbio@gmail.com | China | 11681 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 |
info@gihichemicals.com | China | 49968 | 58 |