Naphazoline hydrochloride manufacturers and suppliers

Naphazoline hydrochloride suppliers

Properties

Melting point:: 254-260 °C

storage temp.: Keep in dark place,Inert atmosphere,Room temperature

solubility: Freely soluble in water, soluble in ethanol (96 per cent).

pka: pKa (25°C) 10.35 ±0.02, (35°C) 10.13 ±0.02, (45°C) 9.92 ±0.03; pKa (25°C) 10.35 ±0.02, (35°C) 10.13 ±0.02, (45°C) 9.92 ±0.03

form: Crystalline Powder

color: White

PH: pH (50g/l, 25℃) : 4.0～6.0

Water Solubility: 170 g/L (20 ºC)

Sensitive: Hygroscopic

Merck: 14,6368

BRN: 3716843

Stability:: Hygroscopic

InChI: InChI=1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H

InChIKey: DJDFFEBSKJCGHC-UHFFFAOYSA-N

SMILES: C(C1C2C(=CC=CC=2)C=CC=1)C1NCCN=1.[H]Cl

CAS DataBase Reference: 550-99-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H300

Precautionary statements: P264-P270-P301+P310+P330-P405-P501-P301+P310a-P321-P501a

Hazard Codes: T,Xn

Risk Statements: 25-23/24/25-20/21/22

Safety Statements: 45-36/37/39-24/25

RIDADR: UN 2811 6.1/PG 2

WGK Germany: 3

RTECS: NJ4375000

HazardClass: 6.1

PackingGroup: III

HS Code: 29339900

Hazardous Substances Data: 550-99-2(Hazardous Substances Data)

Toxicity: LD50 s.c. in rats: 385 mg/kg (Gylfe)

Use

Naphazoline hydrochloride, is commonly used as a vasoconstrictor in the hospital's otorhinolaryngology and ophthalmology ,it is a adrenomimetic drug ,it has a strong effect on contraction of blood vessels and blood pressure elevation,it has inhibition effect on the central nervous system,by contraction of local vascular, it can play an anti-inflammatory and analgesic role in the local inflammatory lesions , and can eliminate congestion due to fatigue or other reasons. Clinically it is used for the treatment of colds, acute and chronic rhinitis, allergic conjunctivitis, allergic and inflammatory nasal congestion embolism. Local long-term use can lead to blood flow reduction in medication area, which causes resistance decreasing , and results in superinfection. It can not be taken orally. Dropping excess liquid or high concentrations can cause poisoning. Care should be taken, especially in children. Infants, hypertension, hyperthyroidism patients should take with caution, atrophic rhinitis patients are banned. The interval time of dropping , is preferably not less than 4 to 6 hours. The above information is edited by the chemicalbook of Tian Ye.

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