Terutroban
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1物価
選択条件：
ブランド
- 富士フイルム和光純薬株式会社(wako)
パッケージ
- 10mg
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC5568
- 製品説明
- 英語製品説明S 18886
- 包装単位10mg
- 価格￥46000
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| 富士フイルム和光純薬株式会社(wako) | W01TOC5568 | S 18886 |
10mg | ￥46000 | 2024-03-01 | 購入 |
プロパティ
融点 :189 - 192°C
沸点 :591.8±60.0 °C(Predicted)
比重(密度) :1.38±0.1 g/cm3(Predicted)
貯蔵温度 :Sealed in dry,Store in freezer, under -20°C
溶解性 :Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Sonicated)
酸解離定数(Pka) :4.60±0.10(Predicted)
外見 :Solid
色 :White to Off-White
旋光度（Optical Rotation） :[α]/D 25 to 31°, c =1 in DMSO
InChI :1S/C20H22ClNO4S/c1-13-2-3-14-12-16(6-9-19(14)18(13)10-11-20(23)24)22-27(25,26)17-7-4-15(21)5-8-17/h2-5,7-8,16,22H,6,9-12H2,1H3,(H,23,24)/t16-/m0/s1
InChIKey :HWEOXFSBSQIWSY-INIZCTEOSA-N
SMILES :O=S(N[C@@H]1CC2=CC=C(C)C(CCC(O)=O)=C2CC1)(C3=CC=C(Cl)C=C3)=O
沸点 :591.8±60.0 °C(Predicted)
比重(密度) :1.38±0.1 g/cm3(Predicted)
貯蔵温度 :Sealed in dry,Store in freezer, under -20°C
溶解性 :Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Sonicated)
酸解離定数(Pka) :4.60±0.10(Predicted)
外見 :Solid
色 :White to Off-White
旋光度（Optical Rotation） :[α]/D 25 to 31°, c =1 in DMSO
InChI :1S/C20H22ClNO4S/c1-13-2-3-14-12-16(6-9-19(14)18(13)10-11-20(23)24)22-27(25,26)17-7-4-15(21)5-8-17/h2-5,7-8,16,22H,6,9-12H2,1H3,(H,23,24)/t16-/m0/s1
InChIKey :HWEOXFSBSQIWSY-INIZCTEOSA-N
SMILES :O=S(N[C@@H]1CC2=CC=C(C)C(CCC(O)=O)=C2CC1)(C3=CC=C(Cl)C=C3)=O
安全情報
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| 注意喚起語: | Warning | ||||||||||||||||||||||||||||
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説明
The lipid mediator thromboxane A2 (TXA2) plays a key role in platelet aggregation and vascular and bronchial smooth muscle constriction. The actions of TXA2 are mediated by its specific G protein coupled-receptor, referred to as the TXA2 receptor or TP. S18886 is an orally active, long-acting antagonist of the TP receptor with an IC50 value of 16.4 nM. It inhibits TP receptor-mediated vascular contractions, platelet aggregation, and adhesion and infiltration of monocytes/macrophages in various pre-clinical and clinical models of thrombosis or atherosclerosis. S18886 is the active isomer of the potent TP receptor antagonist, S18204. Antagonists of TP receptors have advantages over aspirin as they not only block the effect of TXA2 on platelets, but also inhibit other ligands such as prostaglandin endoperoxides and isoprostanes.関連商品価格
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