| | 35891-70-4 Basic information More.. |
| Product Name: | MYRIOCIN | | Synonyms: | MYRIOCIN;MYRIOCIN, MYCELIA STERILIA;THERMOZYMOCIDIN;2S-amino-3R,4R-dihydroxy-2-(hydroxymethyl)-14-oxo-6E-eicosenoic acid;Myriocin, 99%, from Mycelia sterilia;Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem;6e))-4s*;6-eicosenoicacid,2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-,(2s-(2r*,3s | | CAS: | 35891-70-4 | | MF: | C21H39NO6 | | MW: | 401.54 | | EINECS: | 636-862-5 | | Mol File: | 35891-70-4.mol |  |
Use
Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus in a murine model.[Cayman Chemical]
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35891-70-4
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Product Name:Myriocin;(2S,3R,4R,6E)-2-AMino-3,4-dihydroxy-2-(hydroxyMethyl)-14-oxo-6-eicosenoic Acid; [2S-(2R*,3S*,4S*,6E)]-2-AMino-3,4-dihydroxy-2-(hydroxyMethyl)-14-oxo-6-eicosenoic Acid; (+)-Myriocin; ISP-I; NSC 177379; TherMozyMocidin; (2S,3R,4R)-(E)-2-AMino-3,4-dihydroxy-2-hydroxyMethyl-14-oxoeicos-6-enoic Acid
CAS:35891-70-4
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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