| | 177355-84-9 Basic information More.. |
| Product Name: | DBeQ | | Synonyms: | DBeQ;2,4-QuinazolinediaMine, N2,N4-bis(phenylMethyl)-;2,4-QuinazolinediaMine, N,N'-bis(phenylMethyl)-;JRF 12;N,N'-Dibenzylquinazoline-2,4-diamine;N2,N4-Dibenzylquinazoline-2,4-diamine;JRF;N,N'-Dibenzylquinazoline-2,4-diamine DBeQ | | CAS: | 177355-84-9 | | MF: | C22H20N4 | | MW: | 340.42 | | EINECS: | | | Mol File: | 177355-84-9.mol |  |
Use
The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM). It does not exhibit activity when tested against a panel 170 protein kinases at concentrations as high as 15 μM. At 10 μM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.[Cayman Chemical]
- DBEQ
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- US $50.00-181.00 / mg
- 2025-07-25
- CAS:177355-84-9
- Min. Order:
- Purity: 99.94%
- Supply Ability: 10g
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177355-84-9
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