| | 504435-15-8 Basic information More.. |
| Product Name: | 11(12)-EpETE | | Synonyms: | 11(12)-EpETE;11(12)-EpETE Exclusive;5,8-Decadienoic acid, 10-[3-(2Z,5Z)-2,5-octadien-1-yl-2-oxiranyl]-, (5Z,8Z)-;11,12-epoxy-5(Z),8(Z),14(Z),17(Z)- eicosatetraenoic acid | | CAS: | 504435-15-8 | | MF: | C20H30O3 | | MW: | 318.45 | | EINECS: | | | Mol File: | 504435-15-8.mol |  |
Use
Eicosapentaenoic acid (EPA; ) is converted to epoxyeicosatetraenoic acids (EpETE) by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, (±)17(18)-EpETE , relaxes vascular and airway smooth muscle by binding large conductance Ca2+-activated K+ (BKCa) channels by directly interacting with BKα channel subunits. (±)11(12)-EpETE is an epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo. The biological actions and physiological effects of this epoxide remain to be determined.[Cayman Chemical]
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504435-15-8
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