| | 1038549-25-5 Basic information More.. |
| Product Name: | CAY10622 | | Synonyms: | CAY10622;BenzaMide, 3-[[[[[4-(aMinocarbonyl)phenyl]aMino]carbonyl]aMino]Methyl]-N-(1,2,3,4-tetrahydro-7-isoquinolinyl)-;3-[[(4-carbamoylphenyl)carbamoylamino]methyl]-N-(1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide;CAY10622 Exclusive;ROCK-IN-10 | | CAS: | 1038549-25-5 | | MF: | C25H25N5O3 | | MW: | 443.5 | | EINECS: | | | Mol File: | 1038549-25-5.mol |  |
Use
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. CAY10622 is a potent, ureidobenzamide inhibitor of ROCK-I and ROCK-II kinases with IC50 values of 6 and 4 nM, respectively. It is inactive (showing greater then 100-fold selectivity) against an additional 44 kinases.[Cayman Chemical]
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1038549-25-5
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