| | 24144-92-1 Basic information More.. |
| Product Name: | TMS | | Synonyms: | (E)-2,3',4,5'-TETRAMETHOXYSTILBENE;2,3',4,5'-TETRAMETHOXYSTILBENE;1-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXY-BENZENE;1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE;3,5,2’,4’-Tetramethoxystilbene;TMS - Trans-2,3',4,5'-tetramethoxystilbene;CS-961;Benzene, 1-[(1E)-2-(3,5-diMethoxyphenyl)ethenyl]-2,4-diMethoxy- | | CAS: | 24144-92-1 | | MF: | C18H20O4 | | MW: | 300.35 | | EINECS: | | | Mol File: | 24144-92-1.mol |  |
Use
CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 μg/ml.
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24144-92-1
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