| | 110117-83-4 Basic information More.. |
| Product Name: | 1-Methyl-D-tryptophan | | Synonyms: | 1-Methyl-D-tryptophane;1-METHYL-D-TRYPTOPHAN 95%;(R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid;Indoximod (NLG-8189）;NLG-8189;Me-D-Trp;1-Me-D-Trp;D-Trp(Me)-OH | | CAS: | 110117-83-4 | | MF: | C12H14N2O2 | | MW: | 218.25 | | EINECS: | | | Mol File: | 110117-83-4.mol |  |
Use
Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.
- Indoximod
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- $64.00
- 2026-07-27
- CAS:110117-83-4
- Purity: 99.55%
- Supply Ability: 10g
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110117-83-4
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