Use
A dibenzoxazepine derivative in use is loxapinesuccinate, 2-chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f ][1,4]oxazepine succinate (Daxolin). The structural relationshipto the phenothiazine antipsychotics is apparent. Examplesin this group are clothiapine, metiapine, zotepine, and others.They have electron-withdrawing groups at position 2, relativelyclose to the side-chain nitrogen atoms. Loxapine, an effectiveantipsychotic, blocks D2-type receptors and has side effectssimilar to those reported for the phenothiazines. Itsmetabolism involves aromatic hydroxylation to give severalphenolic metabolites that have higher affinity for D2 receptorsthan the parent. It is also N-demethylated to yield amoxapine(an antidepressant drug), which inhibits norepinephrine (NE)neurotransporter to block neuronal NE reuptake.