| | 123948-87-8 Basic information More.. |
| Product Name: | Topotecan | | Synonyms: | hycamptamine;HYDROGEN CHLORIDE, BUTANOL REAGENT;HYDROGEN CHLORIDE, METHANOL REAGENT;HYDROGEN CHLORIDE, METHANOL REAGENT 10;HYDROGEN CHLORIDE, METHANOL REAGENT 5;HYDROCHLORIC ACID,1.1M;HYDROCHLORIC ACID, 2.00 N;HYDROCHLORIC ACID, 20 DEG BAUME | | CAS: | 123948-87-8 | | MF: | C23H23N3O5 | | MW: | 421.45 | | EINECS: | 687-471-1 | | Mol File: | 123948-87-8.mol |  |
Use
Topotecan was launched in the US for the second-line treatment of ovarian
cancer. It can be prepared in four steps from camptothecin and is a water soluble
derivative of the natural product with decreased toxicity. Unlike its chemical relative
irinotecan, topotecacan in not a prodrug and does not require bioactivation. It is an
inhibitor of topoisomerase I. Specifically, it inhibits the release of topoisomerase I
from DNA, where it relaxes supercoiled DNA, giving rise to single-strand breaks.
When the replication fork reaches this complex, double-stand breaks can occur. This
signals apoptosis and eventually gives rise to cell death. Evidence indicates
hycamtin is safe for people with impaired hepatic function.
- Topotecan
-
- $32.00
- 2026-05-26
- CAS:123948-87-8
- Purity: 96.14%
- Supply Ability: 10g
- Topotecan USP/EP/BP
-
- $1.10
- 2025-11-18
- CAS:123948-87-8
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
- Topotecan
-
- $65.00
- 2021-11-02
- CAS:123948-87-8
- Min. Order: 1G
- Purity: 99%
- Supply Ability: 10kgs
|
|
123948-87-8
Recommend Suppliers |
|