460738-38-9 Basic information More..
Product Name:ecallantide
Synonyms:ecallantide;DX 88;ecallantide USP/EP/BP;Cys16-Cys40;Cys32-Cys53);H-Glu-Ala-Met-His-Ser-Phe-Cys-Ala-Phe-Lys-Ala-Asp-Asp-Gly-Pro-Cys-Arg-Ala-Ala-His-Pro-Arg-Trp-Phe-Phe-Asn-Ile-Phe-Thr-Arg-Gln-Cys-Glu-Glu-Phe-Ile-Tyr-Gly-Gly-Cys-Glu-Gly-Asn-Gln-Asn-Arg-Phe-Glu-Ser-Leu-Glu-Glu-Cys-Lys-Lys-Met-Cys-Thr-Arg-Asp-OH(Disulfide bridge:Cys7-Cys57
CAS:460738-38-9
MF:C305H442N88O91S8
MW:7053.82798
EINECS:
Mol File:460738-38-9.mol
460738-38-9

Use

Ecallantide, also known as DX-88, was approved in 2009 in the United States for treatment of hereditary angioedema (HAE), a condition characterized by episodic attacks of localized edema in cutaneous and mucosal tissues. HAE results from deficiencies or disorders of C1-esterase inhibitor protein (C1- 1NH). Mutation of the gene that encodes C1-1NH causes the lack or altered activity of the serine protease, C1-1NH. C1-1NH regulates the kallikrein–kinin (contact activation) and complement cascade systems. Ecallantide (DX-88) was designed to inhibit the action of plasma kallikrein. Ecallantide is a potent and selective inhibitor of plasma kallikrein with a Ki= 25 pM. The discovery program that identified ecallantide used phage display technology and a library of designed variants of the first Kunitz domain of TFPI. Ecallantide, a 60-amino acid peptide, with 3-disulfide bonds, differs from TFPI by 7-amino acids. Ecallantide has been developed as a subcutaneous administered formulation.

ecallantide manufacturers

  • Ecallantide
  • US $0.00 / g
  • 2025-05-27
  • CAS:460738-38-9
  • Min. Order: 1g
  • Purity: 98%min
  • Supply Ability: 1000g
  • Ecallantide
  • US $0.00-0.00 / mg
  • 2025-04-28
  • CAS:460738-38-9
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  • Purity:
  • Supply Ability: 10g
  • ecallantide
  • US $10.00 / kg
  • 2024-03-08
  • CAS:460738-38-9
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 1000kg
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