| | 333963-40-9 Basic information More.. |
| Product Name: | lubiprostone | | Synonyms: | (2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-heptanoic acid;Prostan-1-oic acid, 11,15-epoxy-16,16-difluoro-15-hydroxy-9-oxo-, (11alpha,15R)-;Spi 0211;Unii-7662kg2R6k;(2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-h;7-((1R,2R,3R)-2-(4,4-difluoro-3-oxooctyl)-3-hydroxy-5-oxocyclopentyl)heptanoic acid;AMitiza Lubiprostone;7-((2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoic acid | | CAS: | 333963-40-9 | | MF: | C20H32F2O5 | | MW: | 390.46 | | EINECS: | 1312995-182-4 | | Mol File: | 333963-40-9.mol |  |
Use
Chronic constipation is an affliction affecting 4–5 million Americans alone.
When no specific cause is identified, it is classified as idiopathic. Dietary and
lifestyle modifications are the first-line conventional approaches followed by the
administration of laxatives. Unfortunately, chronic idiopathic constipation is frequently
refractory to traditional therapy; thus, the need for novel agents exists.
Lubiprostone is a bicyclic fatty acid with a novel mechanism of action. Without
affecting sodium and potassium ion concentrations, lubiprostone activates
intestinal chloride ion channels, thereby, increasing intestinal water secretion
and intestinal fluid chloride ion concentration. In basolateral membranepermeabilized
T84 gastrointestinal epithelial cells under chloride gradient conditions,
lubiprostone concentration-dependently increased short-circuit current
with an EC50 of approximately 20 nM.
- Lubiprostone
-
- 2026-09-18
- CAS:333963-40-9
- Min. Order: 1g
- Purity: More Than 99%
- Supply Ability: 100kg/Month
- Lubiprostone
-
- 2026-09-14
- CAS:333963-40-9
- Min. Order: 1G/Bag
- Purity: 99% up
- Supply Ability: 2 tons
- lubiprostone
-
- 2026-06-30
- CAS:333963-40-9
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1000kg
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333963-40-9
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Shanghai Boyle Chemical Co., Ltd.
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| Products Intro: |
Product Name:(2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopentabpyran-5-heptanoic acid
CAS:333963-40-9
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| CB Index: |
55 |
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