| | 61-32-5 Basic information More.. |
| Product Name: | methicillin | | Synonyms: | methicillin;Methcilline;2,6-Dimethoxyphenyl-penicillin, Methicillin Selective Supplement, Methicillin, Staphcillin;MRSA Selective Supplement;(2S,5R,6R)-6-(2,6-Dimethoxybenzoylamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylic acid;2,6-Dimethoxyphenylpenicillin;BRL-1241;Dimocillin | | CAS: | 61-32-5 | | MF: | C17H20N2O6S | | MW: | 380.42 | | EINECS: | 200-505-8 | | Mol File: | 61-32-5.mol |  |
Use
2,6-Dimethoxyphenylpenicillin; methicillin (international
non-proprietary name). The first β-lactamase-resistant semisynthetic
penicillin. It was initially used widely but has been
superseded by other group 3 members and is no longer commercially
available.
It is less active than benzylpenicillin or other group 3
penicillins. It is very stable to staphylococcal
β-lactamase and is active against β-lactamaseproducing
strains of Staph. aureus that do not produce a
functional PBP 2a. Resistance is common among
staphylococci, with the incidence geographically diverse.
Most methicillin-resistant staphylococcal isolates display
multiresistance.
It is not acid resistant, and must therefore be administered
parenterally. About 10% is metabolized, with 60–80% of the
dose excreted in the urine. Toxicity is similar to that of other
group 3 penicillins. Nephritis appears to be more common
than with other penicillins.
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61-32-5
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