Calcium phosphate dibasic
| | 7757-93-9 Basic information More.. |
| Product Name: | Calcium phosphate dibasic | | Synonyms: | calciumdibasicphosphate;calciumperphosphate,ammonified,granular;calciumphosphate(1:1);CALCIUM ORTHOPHOSPHATE;CALCIUM MONOHYDROGEN PHOSPHATE;CALCIUM MONOHYDROGEN PHOSPHATE, DIBASIC;CALCIUM PHOSPHATE, DIBASIC;CALCIUM HYDROGEN ORTHOPHOSPHATE | | CAS: | 7757-93-9 | | MF: | CaHO4P | | MW: | 136.06 | | EINECS: | 231-826-1 | | Mol File: | 7757-93-9.mol |  |
Use
Dibasic calcium phosphate should not be used to formulate
tetracyline antibiotics.
The surface of milled anhydrous dibasic calcium phosphate is
alkaline and consequently it should not be used with drugs that
are sensitive to alkaline pH. However, reports suggest there are
differences in the surface alkalinity/acidity between the milled and
unmilled grades of anhydrous dibasic calcium phosphate; the
unmilled form has an acidic surface environment. This difference
has important implications for drug stability, particularly when
reformulating from, e.g. roller compaction to direct compression,
when the particle size of the anhydrous dibasic calcium phosphate
might be expected to change.
Dibasic calcium phosphate dihydrate has been reported to be
incompatible with a number of drugs and excipients, and many of
these incompatibilities are expected to occur with dibasic calcium
phosphate, anhydrous; see Calcium phosphate, dibasic dihydrate.
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7757-93-9
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