| | 34348-59-9 Basic information More.. |
| Product Name: | ISOEGOMAKETONE | | Synonyms: | ISOEGOMAKETONE;(E)-1-(furan-3-yl)-4-methylpent-2-en-1-one;2-Penten-1-one, 1-(3-furanyl)-4-methyl-, (2E)-;(2E)-1-(3-Furyl)-4-methyl-2-penten-1-one;(2E)-1-(Furan-3-yl)-4-methylpent-2-en-1-one;(E)-1-(Furan-3-yl)-4-methylpent-2-en-1-one - [F90363] | | CAS: | 34348-59-9 | | MF: | C10H12O2 | | MW: | 164.2 | | EINECS: | | | Mol File: | 34348-59-9.mol |  |
Use
This compound tested in in vivo models of B16 melanoma gave a significant cellgrowth inhibition. The tumor cells show an ROS-mediated mitochondria-dependentapoptotic-type death in sub-G1 cell cycle. Iso-egomaketone seemed to generateROS in cells as well as upregulation of Bax and Bcl-2expression (Russo et al. 2015;Shen et al. 2012).
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34348-59-9
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