| | 146374-27-8 Basic information More.. |
| Product Name: | tert-Butanesulfinamide | | Synonyms: | TERT-BUTYLSULPHINAMIDE;T-BUTYLSULFINAMIDE;2-METHYL-2-PROPANESULFINAMIDE, RACEMIC,&;Racemic 2-Methyl-2-propanesulfinamide;TERT-BUTANESULFINAMIDE;(S)-(-)-2-METHYL-2-PROPANESULFINAMIDE, 98+%;2-Methyl-2-propanesulfamide;S-(-)-2-Methyl-2-propanesulfinamide | | CAS: | 146374-27-8 | | MF: | C4H11NOS | | MW: | 121.2 | | EINECS: | 1312995-182-4 | | Mol File: | 146374-27-8.mol |  |
Use
(S)-tert-Butanesulfinamide (also known as 2-Methyl-2-propanesulfinamide) is used for the synthesis of 4-sulfonyliminopiperidine and its reaction with benzyl Grignard to form an important pharmaceutical building block, 4-benzyl-4-aminopiperidne.It can be also used to prepare spiro tosylaziridines via methylene insertion into the derived sulfonylimine1,2-(R)-(+)-2-Methyl-2-propanesulfinamide may be used to prepare N-(1-cyclohexylmethylidene)-2-methylpropane-2-sulfinamide via copper mediated condensation with cyclohexane carboxaldehyde. It may also be used to prepare (20E)-N-[t-butyl-(R)-sulfinyl]-3-(t-butyldimethylsilyloxy)-pregn-5-en-20-imine, an intermediate for the development of androgen receptor antagonists. (S)-(-)-2-Methyl-2-propanesulfinamide may be used to develop benzofuran-based farnesyltransferase inhibitors as anti-cancer agents.
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146374-27-8
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