ITK/TRKA-IN-1
| 中文名称 | ITK/TRKA-IN-1 |
|---|---|
| 中文同义词 | |
| 英文名称 | 4-Morpholineacetamide, N-[2-[(4aS,5aR)-5,5-difluoro-1,4,4a,5,5a,6-hexahydro-5a-methylcycloprop[f]indazol-3-yl]-5-methyl-1H-benzimidazol-6-yl]-N,α-dimethyl-, (αS)- |
| 英文同义词 | 4-Morpholineacetamide, N-[2-[(4aS,5aR)-5,5-difluoro-1,4,4a,5,5a,6-hexahydro-5a-methylcycloprop[f]indazol-3-yl]-5-methyl-1H-benzimidazol-6-yl]-N,α-dimethyl-, (αS)-;ITK/TRKA-IN-1;Dual inhibitor of IL-2-inducible T-cell kinase (ITK) and tropomyosin receptor kinase A (TRKA);Modzatinib (ITK kinase-IN-1) (compound I) |
| CAS号 | 2655557-54-1 |
| 分子式 | C25H30F2N6O2 |
| 分子量 | 484.55 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2655557-54-1.mol |
| 结构式 |  |
ITK/TRKA-IN-1 性质
| 沸点 | 714.8±70.0 °C(Predicted) |
|---|---|
| 密度 | 1.41±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 9.93±0.10(Predicted) |
ITK/TRKA-IN-1 是一种ITK/TRKA双重抑制剂，ITK的IC50值为1.0 nM，TRKA的抑制率为 96%。