- 5-Bromo-4,7-diazaindole
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- $0.00 / 25KG
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2025-12-25
- CAS:875781-43-4
- Min. Order: 1KG
- Purity: 98
- Supply Ability: 10000KGS
- 5-Bromo-4,7-diazaindole
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- $5.00 / 1KG
-
2025-09-25
- CAS:875781-43-4
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: g-kg-tons, free sample is available
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| | 5-Bromo-4,7-diazaindole Basic information | | Uses |
| Product Name: | 5-Bromo-4,7-diazaindole | | Synonyms: | 5-BROMO-4,7-DIAZAINDOLE;5H-Pyrrolo[2,3-b]pyrazine, 2-bromo-;2-broMo-5H-pyrrolo[2,3-b]pyrazine 2-broMo-5H-pyrrolo[3,2-b]pyrazine;4H-Pyrrolo[2,3-b]pyrazine, 2-bromo-;5-Bromo-4,7-diazaindole 97%;Upatinib Impurity 94;5-Bromo-4,7-diazaindole - [B0088];2-Bromo-5H-pyrrolo[2,3-b]pyrazine | | CAS: | 875781-43-4 | | MF: | C6H4BrN3 | | MW: | 198.02 | | EINECS: | 1308068-626-2 | | Product Categories: | upadacitinib | | Mol File: | 875781-43-4.mol |  |
| | 5-Bromo-4,7-diazaindole Chemical Properties |
| Boiling point | 265 °C | | density | 2.00 | | Fp | 114 °C | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 10.58±0.50(Predicted) | | form | yellow solid | | Appearance | Light yellow to brown Solid | | InChI | InChI=1S/C6H4BrN3/c7-5-3-9-6-4(10-5)1-2-8-6/h1-3H,(H,8,9) | | InChIKey | KTKMLXBEBKGQGL-UHFFFAOYSA-N | | SMILES | C12NC=CC1=NC(Br)=CN=2 | | CAS DataBase Reference | 875781-43-4 |
| | 5-Bromo-4,7-diazaindole Usage And Synthesis |
| Uses | 5-Bromo-4,7-diazaindole is used as an intermediate in organic synthesis and pharmaceuticals. | | Synthesis | Potassium tert-butoxide (3.70 g, 33.0 mmol) was dissolved in THF (80 mL) under N2 protection. A solution of 5-bromo-3 - ((trimethylsilyl) ethynyl) pyrazine-2-amino (9.00 g, 33.0 mmol) in THF (84 mL) was slowly added dropwise over 30 min. After the dropwise addition, the mixture was stirred at room temperature for 30 min, Reflux reaction 1h, Cooled to room temperature and filtered. The filter cake was washed with ethyl acetate (200 mL) and saturated brine (50 mL x 2), and the aqueous phase was combined. And extracted with ethyl acetate (60 mL x 2). The organic phases were combined. The residue was subjected to column chromatography (eluent: PE / EtOAc (v / v) = 3/1) to give 5-Bromo-4,7-diazaindole 5.0 g of a yellow solid. | | Toxicity evaluation | 5-Bromo-4,7-diazaindole has acute oral toxicity.
| | References | [1] Patent: CN106432246, 2017, A. Location in patent: Paragraph 0543; 0544; 0545
[2] Patent: WO2011/149950, 2011, A2
[3] Patent: WO2012/158785, 2012, A1. Location in patent: Page/Page column 90
[4] Patent: WO2014/81732, 2014, A1. Location in patent: Page/Page column 32
[5] Patent: WO2014/85795, 2014, A1 |
| | 5-Bromo-4,7-diazaindole Preparation Products And Raw materials |
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